Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238786598> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4238786598 abstract "B cells producing high-affinity antibodies are destined to differentiate into memory B cells and plasma cells, but the mechanisms leading to those differentiation pathways are mostly unknown. Here we report that the transcription factor IRF4 is required for the generation of plasma cells. Transgenic mice with conditional deletion of Irf4 in germinal center B cells lacked post-germinal center plasma cells and were unable to differentiate memory B cells into plasma cells. Plasma cell differentiation required IRF4 as well as the transcriptional repressor Blimp-1, which both acted 'upstream' of the transcription factor XBP-1. In addition, IRF4-deficient B cells had impaired expression of activation-induced deaminase and lacked class-switch recombination, suggesting an independent function for IRF4 in this process. These results identify IRF4 as a crucial transcriptional 'switch' in the generation of functionally competent plasma cells. PMID: 16767092 Funding information This work was supported by: NCI NIH HHS, United States Grant ID: CA92625 NCI NIH HHS, United States Grant ID: CA37295 NCI NIH HHS, United States Grant ID: CA098285" @default.
- W4238786598 created "2022-05-12" @default.
- W4238786598 creator A5005637454 @default.
- W4238786598 date "2006-07-07" @default.
- W4238786598 modified "2023-09-23" @default.
- W4238786598 title "Faculty Opinions recommendation of Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination." @default.
- W4238786598 doi "https://doi.org/10.3410/f.1033127.375124" @default.
- W4238786598 hasPublicationYear "2006" @default.
- W4238786598 type Work @default.
- W4238786598 citedByCount "0" @default.
- W4238786598 crossrefType "dataset" @default.
- W4238786598 hasAuthorship W4238786598A5005637454 @default.
- W4238786598 hasConcept C104317684 @default.
- W4238786598 hasConcept C12652872 @default.
- W4238786598 hasConcept C137756551 @default.
- W4238786598 hasConcept C154945302 @default.
- W4238786598 hasConcept C156695909 @default.
- W4238786598 hasConcept C159654299 @default.
- W4238786598 hasConcept C199360897 @default.
- W4238786598 hasConcept C2777212361 @default.
- W4238786598 hasConcept C2778453870 @default.
- W4238786598 hasConcept C2781039887 @default.
- W4238786598 hasConcept C41008148 @default.
- W4238786598 hasConcept C54355233 @default.
- W4238786598 hasConcept C86339819 @default.
- W4238786598 hasConcept C86803240 @default.
- W4238786598 hasConcept C95444343 @default.
- W4238786598 hasConceptScore W4238786598C104317684 @default.
- W4238786598 hasConceptScore W4238786598C12652872 @default.
- W4238786598 hasConceptScore W4238786598C137756551 @default.
- W4238786598 hasConceptScore W4238786598C154945302 @default.
- W4238786598 hasConceptScore W4238786598C156695909 @default.
- W4238786598 hasConceptScore W4238786598C159654299 @default.
- W4238786598 hasConceptScore W4238786598C199360897 @default.
- W4238786598 hasConceptScore W4238786598C2777212361 @default.
- W4238786598 hasConceptScore W4238786598C2778453870 @default.
- W4238786598 hasConceptScore W4238786598C2781039887 @default.
- W4238786598 hasConceptScore W4238786598C41008148 @default.
- W4238786598 hasConceptScore W4238786598C54355233 @default.
- W4238786598 hasConceptScore W4238786598C86339819 @default.
- W4238786598 hasConceptScore W4238786598C86803240 @default.
- W4238786598 hasConceptScore W4238786598C95444343 @default.
- W4238786598 hasLocation W42387865981 @default.
- W4238786598 hasOpenAccess W4238786598 @default.
- W4238786598 hasPrimaryLocation W42387865981 @default.
- W4238786598 hasRelatedWork W1900229962 @default.
- W4238786598 hasRelatedWork W1977287392 @default.
- W4238786598 hasRelatedWork W2043959607 @default.
- W4238786598 hasRelatedWork W2067961064 @default.
- W4238786598 hasRelatedWork W2131933701 @default.
- W4238786598 hasRelatedWork W2145230417 @default.
- W4238786598 hasRelatedWork W2891382498 @default.
- W4238786598 hasRelatedWork W4255211055 @default.
- W4238786598 hasRelatedWork W4294862206 @default.
- W4238786598 hasRelatedWork W2470467374 @default.
- W4238786598 isParatext "false" @default.
- W4238786598 isRetracted "false" @default.
- W4238786598 workType "dataset" @default.