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- W4238789972 abstract "Journal of Paediatrics and Child HealthVolume 50, Issue 3 p. 243-243 Heads UpFree Access Cooling unsuccessful for bacterial meningitis First published: 27 March 2014 https://doi.org/10.1111/jpc.12527_3AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Induced hypothermia is beneficial in brain injury because of neonatal hypoxic ischaemia and in some other brain injuries. A French intensive care unit-based, multi-centre, open-label, randomised controlled trial compared cooling with 32–34°C for 48 h to standardised care for 98 adults with bacterial meningitis and coma.1 Coma was defined as a Glasgow Coma Scale score ≤8. The primary outcome was the Glasgow Outcome Scale: a score of 5 was favourable, whereas 1–4 was an unfavourable outcome. The Data Safety Monitoring Board (DSMB) stopped the trial early when one of the two groups had a significantly higher mortality. The importance of randomising patients and of having controls, as well as the value of DSMB's, was shown when unblinding showed that it was the intervention (cooling) group with the higher mortality (25 of 49 or 51% vs. 15 of 49 controls or 31%, relative risk (RR) = 1.99, 95% CI 1.05–3.77). After adjustment for age, Glasgow Coma Scale score and septic shock at entry, the hazard ratio was 1.76 but no longer statistically significant. At 3 months, 86% of the hypothermia group compared with 74% of controls had an unfavourable outcome (RR = 2.17, 95% CI 0.78–6.01). Moderate hypothermia does not improve outcome in bacterial meningitis and may well make things worse. Reference 1 Mourvillier B et al. JAMA 2013; 310: 2174– 2183. CrossrefCASPubMedWeb of Science®Google Scholar Reviewer: David Isaacs, david.isaacs@health.nsw.gov.au Volume50, Issue3March 2014Pages 243-243 ReferencesRelatedInformation" @default.
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- W4238789972 date "2014-03-01" @default.
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- W4238789972 title "Cooling unsuccessful for bacterial meningitis" @default.
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- W4238789972 doi "https://doi.org/10.1111/jpc.12527_3" @default.
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