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• W4238802022 abstract "Event Abstract Back to Event THE INITIATION OF MONOCYTE APOPTOSIS BY MOREAU BCG IS DIFFERENTLY REGULATED WHEN COMPARED TO PASTEUR AND DANISH BCG STRAINS IN HEALTHY VOLUNTARIES Victor Fonseca1, Thaize Q. Pedro1, Vitor Lima1, Leticia Moreira1, Jessica Lima1, Mariana Siqueira1, Julie Santana1, Carlos Ponte1, Alvaro Bertho2, Thiago Toledo-Pinto3, Milton Moraes3 and Paulo Antas1* 1 FIOCRUZ, Brazil 2 FIOCRUZ, Brazil 3 FIOCRUZ, Brazil Introduction: Tuberculosis (TB) remains the world’s leading cause of mortality. For its control, studies of TB vaccines are needed. Since BCG is the only vaccine against TB currently in use, studies addressing the protective role of BCG is urgent required. Methods: Cohorts of HIV-negative voluntaries have been enrolled: adult Healthy Donors (HD) and neonates Umbilical Vein (UV). Host mononuclear cells were purified directly from whole blood, then BCG Moreau, Pasteur and Danish strains were primarily used for in vitro monocyte infection at 48h, and Annexin V-FITC and PI were employed for apoptosis detection by a flow cytometry approach. The bacilli viability was promptly assessed by an immunofluorescence kit (LIVE/DEAD® BacLight). The supernatant of the cultures were further used for cytokine detection assays. The P levels were setup at < 0.05. Results: Here, the BCG Moreau induced higher apoptosis levels than Pasteur and Danish BCG strains in both HD and UV groups (p<0.05). In addition, we rule out any confounding factor related to storage and viability of the BCG strains used, since all partitions showed virtually the same pattern: 84%, 96% and 95% for live BCG Moreau, Pasteur and Danish, respectively. Remarkably, all BCG strains also induced higher levels (p<0.05) of IL-18, IL-23 and TGF-β1 in the UV group only. Conclusion: The Moreau BCG strain showed superior ability to induce apoptosis when compared with Pasteur and Danish BCG strains. On the other hand, all BCG strains induced similar patterns of in vitro pro and anti-inflammatory cytokines. The vast majority of the world’s current population has been vaccinated with BCG, with the possible requirement for a booster immunization in adulthood for TB protection. A booster immunization with BCG may protect the immunized individuals and further studies that are currently in progress are needed to better evaluate these findings. Acknowledgements Financial support: FAP; Fiocruz; FAPERJ; CNPq Keywords: BCG, Moreau strain, Danish strain, Pasteur strain, Apoptosis Conference: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015. Presentation Type: Poster Presentation Topic: Infectious and parasitic diseases Citation: Fonseca V, Pedro TQ, Lima V, Moreira L, Lima J, Siqueira M, Santana J, Ponte C, Bertho A, Toledo-Pinto T, Moraes M and Antas P (2015). THE INITIATION OF MONOCYTE APOPTOSIS BY MOREAU BCG IS DIFFERENTLY REGULATED WHEN COMPARED TO PASTEUR AND DANISH BCG STRAINS IN HEALTHY VOLUNTARIES. Front. Immunol. Conference Abstract: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología. doi: 10.3389/conf.fimmu.2015.05.00159 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 31 May 2015; Published Online: 14 Sep 2015. * Correspondence: Dr. Paulo Antas, FIOCRUZ, Rio de Janeiro, Brazil, pzuquim@ioc.fiocruz.br Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Victor Fonseca Thaize Q Pedro Vitor Lima Leticia Moreira Jessica Lima Mariana Siqueira Julie Santana Carlos Ponte Alvaro Bertho Thiago Toledo-Pinto Milton Moraes Paulo Antas Google Victor Fonseca Thaize Q Pedro Vitor Lima Leticia Moreira Jessica Lima Mariana Siqueira Julie Santana Carlos Ponte Alvaro Bertho Thiago Toledo-Pinto Milton Moraes Paulo Antas Google Scholar Victor Fonseca Thaize Q Pedro Vitor Lima Leticia Moreira Jessica Lima Mariana Siqueira Julie Santana Carlos Ponte Alvaro Bertho Thiago Toledo-Pinto Milton Moraes Paulo Antas PubMed Victor Fonseca Thaize Q Pedro Vitor Lima Leticia Moreira Jessica Lima Mariana Siqueira Julie Santana Carlos Ponte Alvaro Bertho Thiago Toledo-Pinto Milton Moraes Paulo Antas Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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