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• W4238807684 abstract "Objective: To clarify a pathogenesis and evaluate a therapeutic effect in a disease, it is important that experimental animal model is established and that the lesions in the model are examined pathologically. Experimental rat endometriosis has been developed by uterine autotransplantation already, and has been used in various investigations of endometriosis. However, almost all previous reports are only focused on implanted uterine tissues, therefore, little is known about morphology of the lesions in detail, specifically in peritoneum attached uterine transplants. Design: In this experiment, we induced rat endometriosis by surgical autotransplantation of uterine tissue and examined morphological alterations of uterus-attached peritoneum with light and electron microscope following the time lapse after the implantation. Materials/Methods: SLC-Sprague-Dawley Rats (8-week old) were maintained on a 12-hour (light) to 12-hour (dark) for 2 weeks, and these rats were used for induction of endometriosis models by the surgical autotransplantation technique of uterine square (5 × 5 mm). The mesenteries were autotransplanted as a comparative control. The implanted areas of peritoneum including abdominal muscle were obtained from anesthetized rats at 4, 7, 14 days after uterine autotransplantation and were examined under a light and electron microscope. To detect DNA fragmentation, these samples were analyzed by TUNEL method. In order to examine localization of mast cells and plasma cells in each specimens, these were performed with Toluidine blue stain (for mast cells) and Methylgreen pyronin stain (for plasma cells). Results: On our light and electron microscopic observations in rat endometriosis models, stromal tissues of uterus-attached peritoneum showed proliferation and infiltration of mast cells, eosinophil, plasma cells, lymphocytes and macrophages. These lesions increased following time lapse after implantation, however, these infiltrated cells disappeared and the proliferation declined finally. Our findings suggest that uterine autotransplantation induced infiltration of allergic inflammatory-related cells and proliferative lesion in peritoneal stroma attached endometrial epithelium, these lesions in rat models are similar to those in endometriosis patients. Conclusions: Our findings suggest that uterine autotransplantation induced immune response, which may be hypersensitivity reaction, in peritoneal stroma attached endometrial epithelium. We believe that these morphological data of rat endometriosis are very important to clarify pathogenesis and progress of human endometriosis. Supported By: No support." @default.
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• W4238807684 date "2002-02-01" @default.
• W4238807684 modified "2023-09-26" @default.
• W4238807684 title "Pathological evaluation of rat endometriosis model" @default.
• W4238807684 doi "https://doi.org/10.1016/s0015-0282(01)03018-7" @default.
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