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- W4238889509 abstract "ACUTE carbon monoxide poisoning accounts for approximately 3,500 accidental or suicidal deaths per year in the United States. Many are preventable by medical management based on physiologic understanding. <h3>Pathophysiology</h3> Carbon monoxide poisoning and its mechanism have been known since Claude Bernard reported in 1857 that this gas caused death by hypoxia, consequent on its reversible combination with hemoglobin.<sup>1</sup>The equilibrium reactions were well described by Haldane in 1895.<sup>2</sup>Excellent reviews are available.<sup>3,4</sup> The effects of CO in concentrations encountered clinically are based entirely on its combination with hemoglobin, displacement of oxygen, and consequent disruption of the O<sub>2</sub>transport system. Carbon monoxide competes with O<sub>2</sub>for binding sites on the hemoglobin molecule, and carboxyhemoglobin (COHb) is without practical function as a carrier of O<sub>2</sub>. Because affinity of CO for hemoglobin is 230 to 270 times as great as that of O<sub>2</sub>, the latter is" @default.
- W4238889509 created "2022-05-12" @default.
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- W4238889509 date "1976-09-27" @default.
- W4238889509 modified "2023-10-16" @default.
- W4238889509 title "Carbon monoxide poisoning" @default.
- W4238889509 doi "https://doi.org/10.1001/jama.236.13.1502" @default.
- W4238889509 hasPublicationYear "1976" @default.
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