Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238912117> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4238912117 endingPage "233" @default.
- W4238912117 startingPage "227" @default.
- W4238912117 abstract "Since the spring of 1997, when the Neurology Department of the University Hospital of Crete admitted its first patient, 9 cases (8 neuropathologically confirmed and 1 probable) of sporadic Creutzfeldt-Jakob disease (sCJD) have been recorded. This represents an annual incidence five-fold higher than expected based on the island's population (0.54 million). Molecular analysis of the prion-protein gene (PRNP) showed no mutations in any of the seven CJD cases studied. Five patients (ages 64–88 years) were homozygous for methionine-129 of PRNP and showed the classic sCJD triad (subacute dementia, myoclonus, periodic electroencephalogram). Brains contained Type 1 (unglycosylated 21.5 kDa band) protease-resistant prion protein (PrPres). Two patients (ages 56 and 57 years), both homozygous for valine-129, showed cerebellar ataxia and later dementia not associated with periodic electroencephalogram; brain PrPres was Type 2. Genotyping of 205 Cretan controls showed that methionine-129 homozygosity, a susceptibility factor for sCJD, was significantly higher in this population than in other Caucasian populations (57.0%, n = 205 versus 41.5%, n = 859. These data are the first to relate a high regional incidence rate for sCJD to the distribution of PRNP 129 genotypes in the local population; however, additional factors may be operational." @default.
- W4238912117 created "2022-05-12" @default.
- W4238912117 creator A5002948558 @default.
- W4238912117 creator A5023627965 @default.
- W4238912117 creator A5030449929 @default.
- W4238912117 creator A5040448710 @default.
- W4238912117 creator A5041853631 @default.
- W4238912117 creator A5066228435 @default.
- W4238912117 creator A5068127643 @default.
- W4238912117 creator A5071050099 @default.
- W4238912117 creator A5081249010 @default.
- W4238912117 creator A5090481156 @default.
- W4238912117 creator A5090808902 @default.
- W4238912117 creator A5082992573 @default.
- W4238912117 date "2001-08-01" @default.
- W4238912117 modified "2023-10-14" @default.
- W4238912117 title "Increased incidence of sporadic Creutzfeldt‐Jakob disease on the island of Crete associated with a high rate of PRNP 129‐methionine homozygosity in the local population" @default.
- W4238912117 doi "https://doi.org/10.1002/ana.1285.abs" @default.
- W4238912117 hasPublicationYear "2001" @default.
- W4238912117 type Work @default.
- W4238912117 citedByCount "2" @default.
- W4238912117 crossrefType "journal-article" @default.
- W4238912117 hasAuthorship W4238912117A5002948558 @default.
- W4238912117 hasAuthorship W4238912117A5023627965 @default.
- W4238912117 hasAuthorship W4238912117A5030449929 @default.
- W4238912117 hasAuthorship W4238912117A5040448710 @default.
- W4238912117 hasAuthorship W4238912117A5041853631 @default.
- W4238912117 hasAuthorship W4238912117A5066228435 @default.
- W4238912117 hasAuthorship W4238912117A5068127643 @default.
- W4238912117 hasAuthorship W4238912117A5071050099 @default.
- W4238912117 hasAuthorship W4238912117A5081249010 @default.
- W4238912117 hasAuthorship W4238912117A5082992573 @default.
- W4238912117 hasAuthorship W4238912117A5090481156 @default.
- W4238912117 hasAuthorship W4238912117A5090808902 @default.
- W4238912117 hasConcept C118552586 @default.
- W4238912117 hasConcept C120665830 @default.
- W4238912117 hasConcept C121332964 @default.
- W4238912117 hasConcept C126322002 @default.
- W4238912117 hasConcept C142724271 @default.
- W4238912117 hasConcept C2778147599 @default.
- W4238912117 hasConcept C2779134260 @default.
- W4238912117 hasConcept C2779483572 @default.
- W4238912117 hasConcept C2779875868 @default.
- W4238912117 hasConcept C2780906641 @default.
- W4238912117 hasConcept C2780912031 @default.
- W4238912117 hasConcept C2908647359 @default.
- W4238912117 hasConcept C3019804061 @default.
- W4238912117 hasConcept C515207424 @default.
- W4238912117 hasConcept C54355233 @default.
- W4238912117 hasConcept C61511704 @default.
- W4238912117 hasConcept C71924100 @default.
- W4238912117 hasConcept C86803240 @default.
- W4238912117 hasConcept C99454951 @default.
- W4238912117 hasConceptScore W4238912117C118552586 @default.
- W4238912117 hasConceptScore W4238912117C120665830 @default.
- W4238912117 hasConceptScore W4238912117C121332964 @default.
- W4238912117 hasConceptScore W4238912117C126322002 @default.
- W4238912117 hasConceptScore W4238912117C142724271 @default.
- W4238912117 hasConceptScore W4238912117C2778147599 @default.
- W4238912117 hasConceptScore W4238912117C2779134260 @default.
- W4238912117 hasConceptScore W4238912117C2779483572 @default.
- W4238912117 hasConceptScore W4238912117C2779875868 @default.
- W4238912117 hasConceptScore W4238912117C2780906641 @default.
- W4238912117 hasConceptScore W4238912117C2780912031 @default.
- W4238912117 hasConceptScore W4238912117C2908647359 @default.
- W4238912117 hasConceptScore W4238912117C3019804061 @default.
- W4238912117 hasConceptScore W4238912117C515207424 @default.
- W4238912117 hasConceptScore W4238912117C54355233 @default.
- W4238912117 hasConceptScore W4238912117C61511704 @default.
- W4238912117 hasConceptScore W4238912117C71924100 @default.
- W4238912117 hasConceptScore W4238912117C86803240 @default.
- W4238912117 hasConceptScore W4238912117C99454951 @default.
- W4238912117 hasIssue "2" @default.
- W4238912117 hasLocation W42389121171 @default.
- W4238912117 hasOpenAccess W4238912117 @default.
- W4238912117 hasPrimaryLocation W42389121171 @default.
- W4238912117 hasRelatedWork W1895282722 @default.
- W4238912117 hasRelatedWork W1983570253 @default.
- W4238912117 hasRelatedWork W2029057539 @default.
- W4238912117 hasRelatedWork W2050968892 @default.
- W4238912117 hasRelatedWork W2739287974 @default.
- W4238912117 hasRelatedWork W2794379415 @default.
- W4238912117 hasRelatedWork W2982170203 @default.
- W4238912117 hasRelatedWork W4206678828 @default.
- W4238912117 hasRelatedWork W4224216340 @default.
- W4238912117 hasRelatedWork W4246762618 @default.
- W4238912117 hasVolume "50" @default.
- W4238912117 isParatext "false" @default.
- W4238912117 isRetracted "false" @default.
- W4238912117 workType "article" @default.