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- W4238951027 abstract "Thirty-two patients with burns of 45 per cent or more were studied prospectively with serial (twice weekly) measurements of variables of host resistance against bacterial infection (neutrophil function, opsonization, C8, factor B, properdin and IgG). Thirty-seven episodes of bacteraemia occurred in 23 patients. Analysis of the immunological profiles immediately preceding and following each of the 37 bacteraemic episodes revealed predisposing abnórmalities in 33. Of the 4 remaining bacteraemic episodes, studies were incomplete in 3. Neutrophil function was abnormal (neutrophil bactericidal index 4-0 or more) preceding 20 instances, normal or mildly abnormal in 8 and not done in 9. Abnormalities of opsonization preceded 18 of the 37 episodes.Circulating levels of C3 increased in the serum of patients associated with 23 episodes of bacteraemia and fell during 12 episodes. In all but one of the 12 episodes where C3 fell, there was an associated decrease in the opsonic index, but the opsonic index fell in 9 other patients without concomitant reduction in C3. Factor B rose during 18 episodes of bacteraemia, fell during 16, remained unchanged in 1 and could not be done in 2 because the patients died. However, factor B levels were always higher than normal. Properdin levels increased during 18 episodes, fell during 14 and remained unchanged in 1 (not available for 4 episodes). Strong evidence for consumption of opsonic proteins [a drop of 50 per cent or more in opsonic index associated with a fall in C3(B)] occurred in 5 episodes with suggestive evidence (drop of 25–49 per cent) in 2 others. In only 2 instances did factor B and properdin seem to be involved in a consumptive process.These data provide evidence that defects in both neutrophil bactericidal activity and opsonization predispose to bacterial infections in seriously burned patients." @default.
- W4238951027 created "2022-05-12" @default.
- W4238951027 date "1979-09-01" @default.
- W4238951027 modified "2023-09-25" @default.
- W4238951027 title "Lymphocyte functions" @default.
- W4238951027 doi "https://doi.org/10.1016/0305-4179(79)90053-6" @default.
- W4238951027 hasPublicationYear "1979" @default.
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