Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238959152> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4238959152 endingPage "601" @default.
- W4238959152 startingPage "600" @default.
- W4238959152 abstract "T-cell receptor (TCR) Vbeta-expression analysis by complementarity-determining region 3 (CDR3)-size spectratyping can identify the reactive populations in an immunologic response. This analysis was used in this study to characterize the Vbeta responses of C57BL/6 (B6) CD4+ and CD8+ T cells directed to either alloantigen (against [B6xDBA/2]F1; anti-H2d) or the syngeneic myeloid leukemia MMB3.19. Vbeta families exhibiting reactivity to the leukemia cells were then enriched for and administered in both syngeneic and allogeneic hematopoietic stem cell transplantation (HSCT) models to assess in vivo graft-versus-leukemia (GVL) potential. In syngeneic transplants, enrichment for pools of selected Vbeta families (Vbeta7, -11, and -13) of T cells or for a single Vbeta family (Vbeta7) of CD4+ T cells conveyed a beneficial GVL response to the recipients. Furthermore, in the haploidentical allogeneic model, both Vbeta6,7-enriched donor B6 T cells and Vbeta7-enriched CD4+ T cells exhibited significant GVL responses with concomitant minimization of graft-versus-host disease (GVHD) development compared with equal numbers of unfractionated T cells. These results suggest that CDR3-size spectratype analysis of and subsequent selection from donor T-cell repertoires can be an effective approach to separate GVL and GVHD potential following allogeneic HSCT.Biol Blood Marrow Transplant 2001;7(4):187-96." @default.
- W4238959152 created "2022-05-12" @default.
- W4238959152 creator A5004665101 @default.
- W4238959152 creator A5025608456 @default.
- W4238959152 creator A5030729248 @default.
- W4238959152 creator A5035183614 @default.
- W4238959152 creator A5058395077 @default.
- W4238959152 creator A5066731396 @default.
- W4238959152 creator A5072512711 @default.
- W4238959152 creator A5077415247 @default.
- W4238959152 date "2004-11-01" @default.
- W4238959152 modified "2023-09-26" @default.
- W4238959152 title "Limited clonality in autoimmunity: drivers and regulators" @default.
- W4238959152 doi "https://doi.org/10.1016/j.autrev.2004.08.017" @default.
- W4238959152 hasPublicationYear "2004" @default.
- W4238959152 type Work @default.
- W4238959152 citedByCount "0" @default.
- W4238959152 crossrefType "journal-article" @default.
- W4238959152 hasAuthorship W4238959152A5004665101 @default.
- W4238959152 hasAuthorship W4238959152A5025608456 @default.
- W4238959152 hasAuthorship W4238959152A5030729248 @default.
- W4238959152 hasAuthorship W4238959152A5035183614 @default.
- W4238959152 hasAuthorship W4238959152A5058395077 @default.
- W4238959152 hasAuthorship W4238959152A5066731396 @default.
- W4238959152 hasAuthorship W4238959152A5072512711 @default.
- W4238959152 hasAuthorship W4238959152A5077415247 @default.
- W4238959152 hasConcept C109159458 @default.
- W4238959152 hasConcept C126322002 @default.
- W4238959152 hasConcept C167672396 @default.
- W4238959152 hasConcept C19317047 @default.
- W4238959152 hasConcept C203014093 @default.
- W4238959152 hasConcept C2776090121 @default.
- W4238959152 hasConcept C2777408962 @default.
- W4238959152 hasConcept C2778461978 @default.
- W4238959152 hasConcept C2780130043 @default.
- W4238959152 hasConcept C28328180 @default.
- W4238959152 hasConcept C2911091166 @default.
- W4238959152 hasConcept C71924100 @default.
- W4238959152 hasConcept C86803240 @default.
- W4238959152 hasConcept C8891405 @default.
- W4238959152 hasConcept C95444343 @default.
- W4238959152 hasConceptScore W4238959152C109159458 @default.
- W4238959152 hasConceptScore W4238959152C126322002 @default.
- W4238959152 hasConceptScore W4238959152C167672396 @default.
- W4238959152 hasConceptScore W4238959152C19317047 @default.
- W4238959152 hasConceptScore W4238959152C203014093 @default.
- W4238959152 hasConceptScore W4238959152C2776090121 @default.
- W4238959152 hasConceptScore W4238959152C2777408962 @default.
- W4238959152 hasConceptScore W4238959152C2778461978 @default.
- W4238959152 hasConceptScore W4238959152C2780130043 @default.
- W4238959152 hasConceptScore W4238959152C28328180 @default.
- W4238959152 hasConceptScore W4238959152C2911091166 @default.
- W4238959152 hasConceptScore W4238959152C71924100 @default.
- W4238959152 hasConceptScore W4238959152C86803240 @default.
- W4238959152 hasConceptScore W4238959152C8891405 @default.
- W4238959152 hasConceptScore W4238959152C95444343 @default.
- W4238959152 hasIssue "7-8" @default.
- W4238959152 hasLocation W42389591521 @default.
- W4238959152 hasOpenAccess W4238959152 @default.
- W4238959152 hasPrimaryLocation W42389591521 @default.
- W4238959152 hasRelatedWork W121072472 @default.
- W4238959152 hasRelatedWork W1969336096 @default.
- W4238959152 hasRelatedWork W1998722022 @default.
- W4238959152 hasRelatedWork W2009840236 @default.
- W4238959152 hasRelatedWork W2146387239 @default.
- W4238959152 hasRelatedWork W2366793411 @default.
- W4238959152 hasRelatedWork W2386230525 @default.
- W4238959152 hasRelatedWork W2395359901 @default.
- W4238959152 hasRelatedWork W2414647507 @default.
- W4238959152 hasRelatedWork W2944683649 @default.
- W4238959152 hasVolume "3" @default.
- W4238959152 isParatext "false" @default.
- W4238959152 isRetracted "false" @default.
- W4238959152 workType "article" @default.