FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238974992> ?p ?o ?g. }

• W4238974992 abstract "Abstract Background: The Cognitive Reserve (CR) theory posits that brains with higher reserve can cope with more cerebral damage to minimize clinical manifestations. The aim of this study was to examine the effect of education (CR proxy) on brain structure and function in Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI) patients and in cognitively healthy elderly (HC) individuals. Methods: Fifty-seven AD patients, 57 aMCI patients and 48 HCs were included to investigate the relationships between education years and gray matter volume (GMV), regional homogeneity (ReHo) and functional connectivity (FC) in brain regions to show associations with both structure and function. Taking the severity of the disease into account, we further assessed the relationships in AD stratified analyses. We then compared more highly (higher CR) and less highly educated (lower CR) subjects at the same level of cognitive impairment. Results: In AD group, the GMV of the dorsal anterior cingulate cortex (dACC) and ReHo in the left inferior temporal cortex (ITC) were inversely associated with education years, after adjustment for age, sex, Mini-Mental State Examination (MMSE), and total intracranial volume or head motion parameters. Seed-based FC analyses revealed that education years were negatively correlated with the FC between the left anterior ITC and left mid frontal cortex as well as right superior frontal cortex and right angular gyrus. Stratified analyses results indicated that this negative relation between education and GMV, ReHo, FC was mainly present in mild AD, which was attenuated in moderate AD and aMCI groups. In mild and moderate AD groups, subjects with higher CR had smaller regional GMV of the dACC and lower ReHo in the left ITC than the subjects with lower CR. No significant differences were found in severe AD and aMCI groups. Conclusions: Our results support the CR theory, and suggest that CR may be protective against AD related brain pathology at the early stage of clinical dementia. These findings could provide the locus of CR-related functional brain mechanisms and a specific time-window for therapeutic interventions to help AD patients to cope better with the brain pathological damage by increasing CR." @default.
• W4238974992 created "2022-05-12" @default.
• W4238974992 creator A5001284314 @default.
• W4238974992 creator A5015983532 @default.
• W4238974992 creator A5029027334 @default.
• W4238974992 creator A5029161082 @default.
• W4238974992 creator A5029946023 @default.
• W4238974992 creator A5041733363 @default.
• W4238974992 creator A5060475357 @default.
• W4238974992 creator A5075626215 @default.
• W4238974992 creator A5077914684 @default.
• W4238974992 creator A5081100015 @default.
• W4238974992 creator A5091076011 @default.
• W4238974992 date "2020-09-14" @default.
• W4238974992 modified "2023-09-24" @default.
• W4238974992 title "The Protective Impact of Education on Brain Structure and Function in Alzheimer’s Disease" @default.
• W4238974992 doi "https://doi.org/10.21203/rs.3.rs-73112/v1" @default.
• W4238974992 hasPublicationYear "2020" @default.
• W4238974992 type Work @default.
• W4238974992 citedByCount "0" @default.
• W4238974992 crossrefType "posted-content" @default.
• W4238974992 hasAuthorship W4238974992A5001284314 @default.
• W4238974992 hasAuthorship W4238974992A5015983532 @default.
• W4238974992 hasAuthorship W4238974992A5029027334 @default.
• W4238974992 hasAuthorship W4238974992A5029161082 @default.
• W4238974992 hasAuthorship W4238974992A5029946023 @default.
• W4238974992 hasAuthorship W4238974992A5041733363 @default.
• W4238974992 hasAuthorship W4238974992A5060475357 @default.
• W4238974992 hasAuthorship W4238974992A5075626215 @default.
• W4238974992 hasAuthorship W4238974992A5077914684 @default.
• W4238974992 hasAuthorship W4238974992A5081100015 @default.
• W4238974992 hasAuthorship W4238974992A5091076011 @default.
• W4238974992 hasBestOaLocation W42389749921 @default.
• W4238974992 hasConcept C126322002 @default.
• W4238974992 hasConcept C15744967 @default.
• W4238974992 hasConcept C169760540 @default.
• W4238974992 hasConcept C169900460 @default.
• W4238974992 hasConcept C2778402161 @default.
• W4238974992 hasConcept C2779134260 @default.
• W4238974992 hasConcept C2984915365 @default.
• W4238974992 hasConcept C3018011982 @default.
• W4238974992 hasConcept C502032728 @default.
• W4238974992 hasConcept C548259974 @default.
• W4238974992 hasConcept C67739388 @default.
• W4238974992 hasConcept C71924100 @default.
• W4238974992 hasConceptScore W4238974992C126322002 @default.
• W4238974992 hasConceptScore W4238974992C15744967 @default.
• W4238974992 hasConceptScore W4238974992C169760540 @default.
• W4238974992 hasConceptScore W4238974992C169900460 @default.
• W4238974992 hasConceptScore W4238974992C2778402161 @default.
• W4238974992 hasConceptScore W4238974992C2779134260 @default.
• W4238974992 hasConceptScore W4238974992C2984915365 @default.
• W4238974992 hasConceptScore W4238974992C3018011982 @default.
• W4238974992 hasConceptScore W4238974992C502032728 @default.
• W4238974992 hasConceptScore W4238974992C548259974 @default.
• W4238974992 hasConceptScore W4238974992C67739388 @default.
• W4238974992 hasConceptScore W4238974992C71924100 @default.
• W4238974992 hasLocation W42389749921 @default.
• W4238974992 hasLocation W42389749922 @default.
• W4238974992 hasLocation W42389749923 @default.
• W4238974992 hasOpenAccess W4238974992 @default.
• W4238974992 hasPrimaryLocation W42389749921 @default.
• W4238974992 hasRelatedWork W2015349939 @default.
• W4238974992 hasRelatedWork W2180085651 @default.
• W4238974992 hasRelatedWork W2184966896 @default.
• W4238974992 hasRelatedWork W2317758322 @default.
• W4238974992 hasRelatedWork W2772053469 @default.
• W4238974992 hasRelatedWork W2954842119 @default.
• W4238974992 hasRelatedWork W3008725040 @default.
• W4238974992 hasRelatedWork W3111430648 @default.
• W4238974992 hasRelatedWork W3202775752 @default.
• W4238974992 hasRelatedWork W4321599477 @default.
• W4238974992 isParatext "false" @default.
• W4238974992 isRetracted "false" @default.
• W4238974992 workType "article" @default.