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- W4238994724 abstract "Aim: To evaluate the use of hybrid closed-loop glucose control with faster-acting insulin aspart (Fiasp) in adults with type 1 diabetes (T1D).Research Design and Methods: In a double-blind, multinational, randomized, crossover study, 25 adults with T1D using insulin pump therapy (mean +/- SD, age 38 +/- 9 years, HbA1c 7.4% +/- 0.8% [57 +/- 8 mmol/mol]) underwent two 8-week periods of unrestricted living comparing hybrid closed-loop with Fiasp and hybrid closed-loop with standard insulin aspart in random order. During both interventions the CamAPS FX closed-loop system incorporating the Cambridge model predictive control algorithm was used.Results: In an intention-to-treat analysis, the proportion of time sensor glucose was in the target range (3.9-10.0 mmol/L; primary endpoint) was not different between interventions (75% +/- 8% vs. 75% +/- 8% for hybrid closed-loop with Fiasp vs. hybrid closed-loop with standard insulin aspart; mean-adjusted difference -0.6% [95% CI -1.8% to 0.7%]; p < .001 for non-inferiority [non-inferiority margin 5%]). The proportion of time with sensor glucose less than 3.9 mmol/L (median [IQR] 2.4% [1.2%-3.2%] vs. 2.9% [1.7%-4.0%]; p = .01) and less than 3.0 mmol/L (median [IQR] 0.4% [0.2%-0.7%] vs. 0.7% [0.2%-0.9%]; p = .03) was reduced with Fiasp versus standard insulin aspart. There was no difference in mean glucose (8.1 +/- 0.8 vs. 8.0 +/- 0.8 mmol/L; p = .13) or glucose variability (SD of sensor glucose 2.9 +/- 0.5 vs. 2.9 +/- 0.5 mmol/L; p = .90). Total daily insulin requirements did not differ (49 +/- 15 vs. 49 +/- 15 units/day; p = .45). No severe hypoglycaemia or ketoacidosis occurred.Conclusions: The use of Fiasp in the CamAPS FX closed-loop system may reduce hypoglycaemia without compromising glucose control compared with standard insulin aspart in adults with T1D." @default.
- W4238994724 created "2022-05-12" @default.
- W4238994724 date "2021-01-24" @default.
- W4238994724 modified "2023-09-27" @default.
- W4238994724 title "Review for Hybrid closed‐loop glucose control with faster insulin aspart (Fiasp) compared with standard insulin aspart in adults with type 1 diabetes: a double‐blind, multicentre, multinational, randomised, crossover study" @default.
- W4238994724 doi "https://doi.org/10.1111/dom.14355/v1/review6" @default.
- W4238994724 hasPublicationYear "2021" @default.
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