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- W4238995909 abstract "Several studies highlighted functional connectivity disruption in mild cognitive impairment (MCI) patients between the hippocampus and other brain regions. The hippocampus is made of several subregions (the Dentate Gyrus (DG), the four fields of the cornu ammonis (CA1–4) and the subiculum (SUB)) that are differentially sensitive to early AD pathology. Little is known however on the specific connectivity of these different hippocampal subregions and their disruption in early AD. The aim of the present study was to evaluate hippocampal subfield networks in healthy elderly (HE) and their changes in MCI patients. Thirty-six HE (68.7 ± 6.1 years) and 22 MCI patients (72.2 ± 7.1 years) underwent both high-resolution hippocampal MRI acquisition and resting-state functional MRI scans. Hippocampal subfield anatomical seeds were delineated on high-resolution hippocampal scans for bilateral CA1, OTHER (CA2-3-4-DG) and subiculum. Functional connectivity maps were then computed for each region and the functional connectivity network of each hippocampal subregions was obtained across HE. Lastly, connectivity maps were compared between HE and MCI with two-sample t-tests for CA1, OTHER and SUB separately to highlight the regions of increased or decreased connectivity in the MCI compared to the HE within each respective network. Significant differences in hippocampal subregion connectivity network were identified. CA1 was more functionally connected to the amygdala, OTHER was more functionally connected to the left anterior cingulate cortex and left temporal pole, and SUB was more connected to the right orbitofrontal cortex, left superior frontal gyrus, posterior cingulate cortex and middle occipital gyrus (Fig). MCI patients showed reduced connectivity between OTHER and the left anterior cingulate cortex, as well as between SUB and all regions included in the SUB network, while no disconnection was found in the CA1 network (Fig)." @default.
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- W4238995909 date "2015-07-01" @default.
- W4238995909 modified "2023-09-30" @default.
- W4238995909 title "P4-085: Intrinsic connectivity of hippocampal subfields in normal elderly and its disturbance in MCI patients" @default.
- W4238995909 doi "https://doi.org/10.1016/j.jalz.2015.06.1790" @default.
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