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- W4239005035 abstract "Abstract Apolipoprotein E (ApoE) is a multifunctional protein that plays significant roles in important cellular mechanisms in peripheral tissues and is as well expressed in the central nervous system, notably by adult neural stem cells (NSCs) in the hippocampus. Evidence from animal studies suggest that ApoE is critical for adult NSC maintenance. However, whether ApoE has the potential to play a similar role in human NSCs has not been directly investigated. To address this question, we conducted a focused study on APOE gene expression level using an in vitro model of neural differentiation and human induced pluripotent stem cells derived from a neurotypical individual. We found that APOE expression was dramatically decreased as the cells became more differentiated, indicating that APOE expression levels reflect the degree of cellular differentiation during neural induction suggesting a potential role for ApoE in human NSC maintenance. Our findings justify further investigations being carried out to understand whether changes in APOE level can directly impact the neurogenic capacity of human stem cells." @default.
- W4239005035 created "2022-05-12" @default.
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- W4239005035 date "2020-02-15" @default.
- W4239005035 modified "2023-09-23" @default.
- W4239005035 title "Apolipoprotein E (APOE) expression pattern in human induced pluripotent stem cells during in vitro neural induction." @default.
- W4239005035 doi "https://doi.org/10.21203/rs.2.23493/v1" @default.
- W4239005035 hasPublicationYear "2020" @default.
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