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- W4239043455 abstract "Effects of the Organophosphorus Compound, O-ethyl-N-dimethyl-phosphoramidocyanidate (Tabun), on Flavor Aversions, Locomotor Activity, and Rotarod Performance in Rats. ROMANO, J. A., JR., AND LANDAUER M. R. (1986). Fundam. Appl. Toxicol. 6,62–68. An assessment of the behavioral effects of acutely administered anti-cholinesterase compound O-ethyl-N-dimethyl phosphoramidocyanidate (tabun), to male rats was performed in three studies across five dose levels (100–198 μg/kg, sc). Doses of 122 μg/kg or greater produced conditioned flavor aversions. Spontaneous locomotor activity was significantly decreased at doses of 122 μg/kg or greater when compared to vehicle control levels. When administered doses of 168 μg/kg or greater, rats exhibited significant decrements in rotarod performance. In addition, the LD50 of tabun was determined to be 240 μg/kg. Signs of cholinergic intoxication were not apparent until 144 μg/kg tabun or more were given. Behavioral effects were thus obtained at doses that were between 54 and 71% of the LD50." @default.
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- W4239043455 date "1986-01-01" @default.
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- W4239043455 title "Effects of the Organophosphorus Compound, O-ethyl-N-dimethyl phosphoramidocyanidate (Tabun), on Flavor Aversions, Locomotor Activity, and Rotarod Performance in Rats" @default.
- W4239043455 doi "https://doi.org/10.1093/toxsci/6.1.62" @default.
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