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- W4239075462 abstract "The role of the placenta in controlling the supply of fatty acids to the fetus was investigated in term placentas from non-smokers ( n 5), smokers (>ten cigarettes/d; n 5) and after addition of ethanol at 2 mg/ml ( n 4). The maternal side was of the placenta was perfused ex vivo for 90 min with a physiological mixture of fatty acids and fatty acid:human albumin ratio. There was no effect of smoking on the transfer of linoleic (LA, 18 : 2 n -6), α-linolenic (αLN, 18 : 3 n -3), arachidonic (AA, 20 : 4 n -6) or docosahexaenoic acid (DHA, 22 : 6 n -3), expressed per perfused area (calculated from H 2 18 O exchange). However, the presence of ethanol in the perfusate at a concentration of 2 mg/ml significantly reduced ( P <0·01) the absolute rate of transfer of the two n -3 polyunsaturated fatty acids, αLN and DHA. This specific effect of ethanol on αLN and DHA also resulted in an altered selectivity for transfer of individual fatty acids. In the non-smoking control group the placenta selectively transferred polyunsaturated fatty acids to the fetus in the order DHA>AA>αLN>LA. The order of selectivity was unaltered in placentas from smokers, but the addition of ethanol to the perfusion medium altered the order of selectivity to AA>αLN>LA>DHA. The presence of ethanol in the perfusate was also associated with a significant reduction ( P <0·05) in the clearance of H 2 18 O. These results suggest that the presence of ethanol at a concentration of 2 mg/ml may reduce the availability of polyunsaturated fatty acids to the developing fetus." @default.
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- W4239075462 date "2002-03-01" @default.
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- W4239075462 title "The effect of maternal smoking and ethanol on fatty acid transport by the human placenta" @default.
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- W4239075462 doi "https://doi.org/10.1079/bjn2001514" @default.
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