FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239076586> ?p ?o ?g. }

• W4239076586 abstract "Abstract Background Bacterial bronchopneumonia (BP) is the leading cause of morbidity and mortality in cattle. While the bacterial composition of the bovine upper respiratory tract (URT) has not been studied in detail, the nasopharynx is generally accepted as the primary source of pathogenic bacteria that cause BP. However, it has recently been shown in humans that the oropharynx may act as the primary reservoir for pathogens that reach the lung. The objective was therefore to describe the bacterial microbiota present along the entire cattle respiratory tract to determine which URT niches may contribute the most to the composition of the lung microbiota. Methods Seventeen upper and lower respiratory tract locations were sampled from 15 healthy feedlot steer calves. Samples were collected using a combination of swabs, protected specimen brushes, and saline washes. DNA was extracted from each sample and the 16S rRNA gene (V3-V4) was sequenced. Community composition, alpha-diversity, and beta-diversity were compared among sampling locations. Results Microbiota composition differed across sampling locations, with physiologically and anatomically distinct locations showing different relative abundances of 1,137 observed sequence variants (SVs). An analysis of similarities showed that the lung was more similar to the nasopharynx (R-statistic = 0.091) than it was to the oropharynx (R-statistic = 0.709) or any other URT sampling location. Five distinct metacommunities were identified across all samples after clustering at the genus level using Dirichlet multinomial mixtures. This included a metacommunity found primarily in the lung and nasopharynx that was dominated by Mycoplasma . Further clustering at the SV level showed a shared metacommunity between the lung and nasopharynx that was dominated by Mycoplasma dispar . Other metacommunities found in the nostrils, tonsils, and oral microbiotas were dominated by Moraxella , Fusobacterium , and Streptococcus , respectively. Conclusions The nasopharyngeal bacterial microbiota is most similar to the lung bacterial microbiota and therefore may serve as the primary source of bacteria to the lung. This finding confirms that the nasopharyngeal microbiota should be the focus of research as it relates to the role of the URT microbiota in BP. As well, this microbiota should be the main target for future interventions and pharmaceuticals aimed at controlling and preventing BP." @default.
• W4239076586 created "2022-05-12" @default.
• W4239076586 creator A5015594621 @default.
• W4239076586 creator A5052752248 @default.
• W4239076586 creator A5057357762 @default.
• W4239076586 creator A5058032201 @default.
• W4239076586 creator A5084958126 @default.
• W4239076586 date "2020-02-18" @default.
• W4239076586 modified "2023-10-03" @default.
• W4239076586 title "Topography of the respiratory tract bacterial microbiota in cattle" @default.
• W4239076586 doi "https://doi.org/10.21203/rs.2.23823/v1" @default.
• W4239076586 hasPublicationYear "2020" @default.
• W4239076586 type Work @default.
• W4239076586 citedByCount "0" @default.
• W4239076586 crossrefType "posted-content" @default.
• W4239076586 hasAuthorship W4239076586A5015594621 @default.
• W4239076586 hasAuthorship W4239076586A5052752248 @default.
• W4239076586 hasAuthorship W4239076586A5057357762 @default.
• W4239076586 hasAuthorship W4239076586A5058032201 @default.
• W4239076586 hasAuthorship W4239076586A5084958126 @default.
• W4239076586 hasBestOaLocation W42390765861 @default.
• W4239076586 hasConcept C105702510 @default.
• W4239076586 hasConcept C151437367 @default.
• W4239076586 hasConcept C2777695942 @default.
• W4239076586 hasConcept C2777907754 @default.
• W4239076586 hasConcept C2779644171 @default.
• W4239076586 hasConcept C42062724 @default.
• W4239076586 hasConcept C42972112 @default.
• W4239076586 hasConcept C523546767 @default.
• W4239076586 hasConcept C534529494 @default.
• W4239076586 hasConcept C54355233 @default.
• W4239076586 hasConcept C71924100 @default.
• W4239076586 hasConcept C86803240 @default.
• W4239076586 hasConcept C89423630 @default.
• W4239076586 hasConceptScore W4239076586C105702510 @default.
• W4239076586 hasConceptScore W4239076586C151437367 @default.
• W4239076586 hasConceptScore W4239076586C2777695942 @default.
• W4239076586 hasConceptScore W4239076586C2777907754 @default.
• W4239076586 hasConceptScore W4239076586C2779644171 @default.
• W4239076586 hasConceptScore W4239076586C42062724 @default.
• W4239076586 hasConceptScore W4239076586C42972112 @default.
• W4239076586 hasConceptScore W4239076586C523546767 @default.
• W4239076586 hasConceptScore W4239076586C534529494 @default.
• W4239076586 hasConceptScore W4239076586C54355233 @default.
• W4239076586 hasConceptScore W4239076586C71924100 @default.
• W4239076586 hasConceptScore W4239076586C86803240 @default.
• W4239076586 hasConceptScore W4239076586C89423630 @default.
• W4239076586 hasLocation W42390765861 @default.
• W4239076586 hasLocation W42390765862 @default.
• W4239076586 hasLocation W42390765863 @default.
• W4239076586 hasLocation W42390765864 @default.
• W4239076586 hasOpenAccess W4239076586 @default.
• W4239076586 hasPrimaryLocation W42390765861 @default.
• W4239076586 hasRelatedWork W1997442832 @default.
• W4239076586 hasRelatedWork W2056626133 @default.
• W4239076586 hasRelatedWork W2141640378 @default.
• W4239076586 hasRelatedWork W2187030677 @default.
• W4239076586 hasRelatedWork W2411494581 @default.
• W4239076586 hasRelatedWork W3033028161 @default.
• W4239076586 hasRelatedWork W3131214299 @default.
• W4239076586 hasRelatedWork W4239076586 @default.
• W4239076586 hasRelatedWork W4254744553 @default.
• W4239076586 hasRelatedWork W2343096831 @default.
• W4239076586 isParatext "false" @default.
• W4239076586 isRetracted "false" @default.
• W4239076586 workType "article" @default.