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- W4239077128 abstract "We appreciate the insightful comments from Dr. Bortolloti and her colleagues based on their long experience with a unique and interesting cohort of children and young adults with chronic HBV infection.1 Their observations, published at the time of the Single Topic Conference and well after planning for the conference was concluded,2 emphasize the complexity of pediatric chronic hepatitis B. The experience described from the University of Padova is exactly the type of arduous follow-up required to make appropriate informed decisions about the management of children with chronic HBV infection. The majority of children in this Italian cohort apparently developed infection as the result of intrafamilial spread of HBV; their disease was associated with biochemical and histological abnormalities and resolution of viral replication in most infected persons. This is quite distinct from the course of perinatally acquired HBV, more common in other parts of the world, where viral infection results in little, if any, liver disease during childhood, despite the presence of high levels of HBV in blood. We applaud the work done by Dr. Bortolloti and her colleagues and look forward to similar long-term studies of other cohorts of children with chronic HBV infection from around the world. Clearly, such studies will be needed to make sound recommendations regarding treatment decisions and liver cancer surveillance in children with chronic HBV infection. Funding of international networks for these much needed long-term follow-up and prospective cross-sectional surveys of chronic HBV infection in children would be extremely useful. Benjamin L. Shneider M.D.*, Eve A. Roberts M.D. , Regino P. González-Peralta M.D. , * Visiting Professor of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA, Professor of Pediatrics University of Toronto, Toronto, Canada, Associate Professor of Pediatrics University of Florida, Gainesville, FL." @default.
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- W4239077128 date "2007-01-01" @default.
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- W4239077128 title "Reply:" @default.
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- W4239077128 doi "https://doi.org/10.1002/hep.21566" @default.
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