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• W4239077194 endingPage "1539" @default.
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• W4239077194 abstract "In Brief Purpose: To analyze if endothelin 1 may have an effect on central retinal artery (CRA) blood flow velocities and intraocular pressure (IOP) in retinal detachment. Methods: Using radioimmunoassay, immunoreactive endothelin 1 levels were tested in both plasma and subretinal fluid specimens from patients with retinal detachment, while only plasma specimens from healthy subjects were tested. Central retinal artery Doppler sonography parameters and IOP were measured in eyes with retinal detachment, with and without proliferative vitreoretinopathy, their respective healthy fellow eyes, and normal eyes. Results: Retinal detachment eyes had lower CRA peak systolic velocity and end-diastolic velocity, lower IOP, and higher plasma immunoreactive endothelin 1 levels than normal eyes (P < 0.0001). Eyes with proliferative vitreoretinopathy had lower CRA peak systolic velocity and end-diastolic velocity, higher resistivity index, lower IOP, higher plasma immunoreactive endothelin 1 levels, and higher subretinal fluid immunoreactive endothelin 1 than eyes without proliferative vitreoretinopathy (P < 0.0001). A statistically significant linear correlation was found among CRA parameters, IOP, and subretinal fluid immunoreactive endothelin 1 measurements. Conclusion: Endothelin 1 has shown a close relationship with IOP and CRA blood flow changes associated to retinal detachment as well as with proliferative vitreoretinopathy complications. Eyes with retinal detachment associated or not to proliferative vitreoretinopathy showed reduced central retinal artery flow, which was related to reduced intraocular pressure (P < 0.0001) compared with normal eyes. Increased immunoreactive endothelin 1 levels in plasma and subretinal fluid have been correlated (P < 0.0001) both, with reduced central retinal artery flow and with reduced intraocular pressure." @default.
• W4239077194 created "2022-05-12" @default.
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• W4239077194 date "2013-09-01" @default.
• W4239077194 modified "2023-10-16" @default.
• W4239077194 title "RETINAL DETACHMENT AND PROLIFERATIVE VITREORETINOPATHY" @default.
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• W4239077194 doi "https://doi.org/10.1097/iae.0b013e318285cbef" @default.
• W4239077194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23974951" @default.
• W4239077194 hasPublicationYear "2013" @default.
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