FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239084872> ?p ?o ?g. }

• W4239084872 endingPage "A85" @default.
• W4239084872 startingPage "A85.2" @default.
• W4239084872 abstract "<h3>Introduction</h3> Anti-tumour necrosis factor (TNF)s form a major part of therapy in Crohn’s disease and has a primary non-response rate of 10–30% and a secondary loss of response rate of 5% per patient-year. Myopenia is prevalent in patients with Crohn’s disease who are in clinical remission and can be measured using body composition analysis tools. We hypothesise that body composition can predict for outcomes of anti-TNF primary non-response and secondary loss of response. <h3>Methods</h3> Between January 2007 to June 2012, 650 anti-TNF naïve patients underwent anti-TNF therapy for Crohn’s disease in a single centre. CT images were analysed for body composition parameters and used to estimate body fat-free mass. The outcome measures were primary non-response and secondary loss of response. COX-regression analysis was used to predict for outcomes with three-year follow-up data. A hypothetical dose of 5 mg/kg was delivered with estimated tissue levels. <h3>Results</h3> Of the 650 patients with anti-TNF therapy, 106 were included. 26 (24.5%) were primary non-responders and 29 (27.4%) had secondary loss of response. 13 patients were obese (BMI > 30). Sex-specific cut-offs that defined a significant association between low muscle, high visceral fat and myosteatosis with outcomes were ascertained by stratification analysis. On multivariate analysis, myopenia predicted for primary non-response (HR 4.74;1.81-12.39,p =0.002) (Figure 1). Large anti-TNF dose variations resulted due to different body compositions. (Figure 2) <h3>Conclusion</h3> In this cohort study with three-year follow-up data, body composition profiles varied widely and did not correlate well with BMI. Myopenia was a predictor of primary non-response with potential implications for dosing and serves as an explanation for pharmacokinetic failure. <h3>Disclosure of Interest</h3> None Declared" @default.
• W4239084872 created "2022-05-12" @default.
• W4239084872 creator A5011808178 @default.
• W4239084872 creator A5020895679 @default.
• W4239084872 creator A5021096157 @default.
• W4239084872 creator A5026738462 @default.
• W4239084872 creator A5034922182 @default.
• W4239084872 creator A5062703106 @default.
• W4239084872 creator A5066865725 @default.
• W4239084872 creator A5071831801 @default.
• W4239084872 creator A5083603154 @default.
• W4239084872 date "2016-06-01" @default.
• W4239084872 modified "2023-09-26" @default.
• W4239084872 title "PTU-067 Body Composition Profiling is a Predictor of Therapeutic Outcome in Patients with Moderate to Severe Crohn’s Disease" @default.
• W4239084872 doi "https://doi.org/10.1136/gutjnl-2016-312388.152" @default.
• W4239084872 hasPublicationYear "2016" @default.
• W4239084872 type Work @default.
• W4239084872 citedByCount "0" @default.
• W4239084872 crossrefType "journal-article" @default.
• W4239084872 hasAuthorship W4239084872A5011808178 @default.
• W4239084872 hasAuthorship W4239084872A5020895679 @default.
• W4239084872 hasAuthorship W4239084872A5021096157 @default.
• W4239084872 hasAuthorship W4239084872A5026738462 @default.
• W4239084872 hasAuthorship W4239084872A5034922182 @default.
• W4239084872 hasAuthorship W4239084872A5062703106 @default.
• W4239084872 hasAuthorship W4239084872A5066865725 @default.
• W4239084872 hasAuthorship W4239084872A5071831801 @default.
• W4239084872 hasAuthorship W4239084872A5083603154 @default.
• W4239084872 hasConcept C126322002 @default.
• W4239084872 hasConcept C2779134260 @default.
• W4239084872 hasConcept C2779280984 @default.
• W4239084872 hasConcept C2780132546 @default.
• W4239084872 hasConcept C2780221984 @default.
• W4239084872 hasConcept C38180746 @default.
• W4239084872 hasConcept C50382708 @default.
• W4239084872 hasConcept C71924100 @default.
• W4239084872 hasConcept C90924648 @default.
• W4239084872 hasConceptScore W4239084872C126322002 @default.
• W4239084872 hasConceptScore W4239084872C2779134260 @default.
• W4239084872 hasConceptScore W4239084872C2779280984 @default.
• W4239084872 hasConceptScore W4239084872C2780132546 @default.
• W4239084872 hasConceptScore W4239084872C2780221984 @default.
• W4239084872 hasConceptScore W4239084872C38180746 @default.
• W4239084872 hasConceptScore W4239084872C50382708 @default.
• W4239084872 hasConceptScore W4239084872C71924100 @default.
• W4239084872 hasConceptScore W4239084872C90924648 @default.
• W4239084872 hasIssue "Suppl 1" @default.
• W4239084872 hasLocation W42390848721 @default.
• W4239084872 hasOpenAccess W4239084872 @default.
• W4239084872 hasPrimaryLocation W42390848721 @default.
• W4239084872 hasRelatedWork W1983516269 @default.
• W4239084872 hasRelatedWork W2034536484 @default.
• W4239084872 hasRelatedWork W2050583520 @default.
• W4239084872 hasRelatedWork W2131408481 @default.
• W4239084872 hasRelatedWork W2530985076 @default.
• W4239084872 hasRelatedWork W2606738175 @default.
• W4239084872 hasRelatedWork W2810268285 @default.
• W4239084872 hasRelatedWork W2884570425 @default.
• W4239084872 hasRelatedWork W3120835417 @default.
• W4239084872 hasRelatedWork W3184875481 @default.
• W4239084872 hasVolume "65" @default.
• W4239084872 isParatext "false" @default.
• W4239084872 isRetracted "false" @default.
• W4239084872 workType "article" @default.