Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239087189> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4239087189 abstract "Abstract Pneumonia accounts for approximately 15% mortalities in adolescents worldwide. MicroRNAs (miRNAs) regulate numerous diseases including pneumonia. miRNA and mRNA expression levels were detected by real time polymerase chain reaction (RT-qPCR). Protein expression levels were determined by enzyme-linked immunosorbent assay (ELISA) and western blot. The interaction between phosphatase and tensin homolog on chromosome ten (PTEN) and miR-103a-3p was explored by dual luciferase reporter assay. Cell viability and cell apoptosis were detected by cell Counting Kit-8 (CCK-8) and flow cytometry. Herein, we discovered that PTEN was decreased and miR-103a-3p was overexpressed in Ana-1 cells of in vitro pneumonia model. miR-103a-3p downregulated the expression levels of PTEN. AntagomiR-103a-3p reversed the increased cell apoptosis and decreased cell viability and inflammatory cytokine expression levels (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-6) induced by LPS in Ana-1 cells by PTEN. AntagomiR-103a-3p inhibited the activation of PTEN/PI3K/AKT/NF-κB signaling pathway induced by LPS in Ana-1 cells. Taken together, our findings exhibited that miR-103a-3p attenuated LPS induced pneumonia by blocking the activation of PTEN/PI3K/AKT/NF-κB signaling pathway and the following cell apoptosis as well as release of proinflammatory cytokines, suggesting that miR-103a-3p might serve as a novel therapeutic target for the treatment of pneumonia." @default.
- W4239087189 created "2022-05-12" @default.
- W4239087189 creator A5036824892 @default.
- W4239087189 creator A5073847195 @default.
- W4239087189 creator A5075596275 @default.
- W4239087189 creator A5079057328 @default.
- W4239087189 creator A5079210379 @default.
- W4239087189 date "2020-01-09" @default.
- W4239087189 modified "2023-10-16" @default.
- W4239087189 title "MiR-103a-3p antagonism attenuates pneumonia via inactivating the PI3K/AKT/NF-κB signaling pathway by targeting PTEN" @default.
- W4239087189 doi "https://doi.org/10.21203/rs.2.20468/v1" @default.
- W4239087189 hasPublicationYear "2020" @default.
- W4239087189 type Work @default.
- W4239087189 citedByCount "0" @default.
- W4239087189 crossrefType "posted-content" @default.
- W4239087189 hasAuthorship W4239087189A5036824892 @default.
- W4239087189 hasAuthorship W4239087189A5073847195 @default.
- W4239087189 hasAuthorship W4239087189A5075596275 @default.
- W4239087189 hasAuthorship W4239087189A5079057328 @default.
- W4239087189 hasAuthorship W4239087189A5079210379 @default.
- W4239087189 hasBestOaLocation W42390871891 @default.
- W4239087189 hasConcept C104317684 @default.
- W4239087189 hasConcept C145059251 @default.
- W4239087189 hasConcept C164027704 @default.
- W4239087189 hasConcept C17991360 @default.
- W4239087189 hasConcept C190283241 @default.
- W4239087189 hasConcept C203014093 @default.
- W4239087189 hasConcept C2776914184 @default.
- W4239087189 hasConcept C2777609662 @default.
- W4239087189 hasConcept C2779549131 @default.
- W4239087189 hasConcept C502942594 @default.
- W4239087189 hasConcept C53227056 @default.
- W4239087189 hasConcept C55493867 @default.
- W4239087189 hasConcept C62478195 @default.
- W4239087189 hasConcept C75217442 @default.
- W4239087189 hasConcept C86554907 @default.
- W4239087189 hasConcept C86803240 @default.
- W4239087189 hasConcept C95444343 @default.
- W4239087189 hasConceptScore W4239087189C104317684 @default.
- W4239087189 hasConceptScore W4239087189C145059251 @default.
- W4239087189 hasConceptScore W4239087189C164027704 @default.
- W4239087189 hasConceptScore W4239087189C17991360 @default.
- W4239087189 hasConceptScore W4239087189C190283241 @default.
- W4239087189 hasConceptScore W4239087189C203014093 @default.
- W4239087189 hasConceptScore W4239087189C2776914184 @default.
- W4239087189 hasConceptScore W4239087189C2777609662 @default.
- W4239087189 hasConceptScore W4239087189C2779549131 @default.
- W4239087189 hasConceptScore W4239087189C502942594 @default.
- W4239087189 hasConceptScore W4239087189C53227056 @default.
- W4239087189 hasConceptScore W4239087189C55493867 @default.
- W4239087189 hasConceptScore W4239087189C62478195 @default.
- W4239087189 hasConceptScore W4239087189C75217442 @default.
- W4239087189 hasConceptScore W4239087189C86554907 @default.
- W4239087189 hasConceptScore W4239087189C86803240 @default.
- W4239087189 hasConceptScore W4239087189C95444343 @default.
- W4239087189 hasLocation W42390871891 @default.
- W4239087189 hasOpenAccess W4239087189 @default.
- W4239087189 hasPrimaryLocation W42390871891 @default.
- W4239087189 hasRelatedWork W12210807 @default.
- W4239087189 hasRelatedWork W1799354 @default.
- W4239087189 hasRelatedWork W18603037 @default.
- W4239087189 hasRelatedWork W22357311 @default.
- W4239087189 hasRelatedWork W36483904 @default.
- W4239087189 hasRelatedWork W37096307 @default.
- W4239087189 hasRelatedWork W4451760 @default.
- W4239087189 hasRelatedWork W12384393 @default.
- W4239087189 hasRelatedWork W33471655 @default.
- W4239087189 hasRelatedWork W42392841 @default.
- W4239087189 isParatext "false" @default.
- W4239087189 isRetracted "false" @default.
- W4239087189 workType "article" @default.