Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239092428> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4239092428 endingPage "1235" @default.
- W4239092428 startingPage "1227" @default.
- W4239092428 abstract "Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. The molecular mechanism of GIST formation is among the best characterized of all human tumors. Activating mutations of the c-Kit-kinase (KIT), a member of the receptor tyrosine kinase III family, are present in 80% of GISTs. Gain-of-function mutations of platelet-derived growth factor receptor A (PDGFRA), a member of the same kinase family, are present in 35% of GISTs that lack KIT mutations. These mutations induce the overexpression and autophosphorylation of KIT and PDGFRA, and result in the activation of downstream signaling pathways. Imatinib, a KIT receptor inhibitor, was developed to treat GIST patients by inactivating signaling pathways. However, some GISTs, especially cases with mutations in exon 13 and 17 of KIT, are resistant to imatinib treatment. Therefore, another approach is needed to develop drugs for GIST treatment. Data also support dysregulation of microRNAs in the progression of many types of cancers. Studies demonstrate that microRNAs directly regulate KIT expression levels in GISTs, and inhibit GIST cell proliferation. This review summarizes the characteristics of GISTs, their molecular and clinical implications, the role of microRNAs in GIST tumorigenesis, and their possible therapeutic potential. Keywords: KIT, PDGFRA, GIST, MicroRNA, RNA therapy, mesenchymal tumor, mutations, Imatinib, cell proliferation, tumorigenesis" @default.
- W4239092428 created "2022-05-12" @default.
- W4239092428 creator A5015420695 @default.
- W4239092428 creator A5026148041 @default.
- W4239092428 creator A5061861055 @default.
- W4239092428 date "2012-12-01" @default.
- W4239092428 modified "2023-09-25" @default.
- W4239092428 title "MicroRNA Involvement in Gastrointestinal Stromal Tumor Tumorigenesis" @default.
- W4239092428 doi "https://doi.org/10.2174/1381612811319070006" @default.
- W4239092428 hasPublicationYear "2012" @default.
- W4239092428 type Work @default.
- W4239092428 citedByCount "0" @default.
- W4239092428 crossrefType "journal-article" @default.
- W4239092428 hasAuthorship W4239092428A5015420695 @default.
- W4239092428 hasAuthorship W4239092428A5026148041 @default.
- W4239092428 hasAuthorship W4239092428A5061861055 @default.
- W4239092428 hasConcept C101544691 @default.
- W4239092428 hasConcept C104317684 @default.
- W4239092428 hasConcept C109159458 @default.
- W4239092428 hasConcept C121608353 @default.
- W4239092428 hasConcept C145059251 @default.
- W4239092428 hasConcept C16930146 @default.
- W4239092428 hasConcept C2022786 @default.
- W4239092428 hasConcept C2775922572 @default.
- W4239092428 hasConcept C2777007597 @default.
- W4239092428 hasConcept C2777583451 @default.
- W4239092428 hasConcept C2778729363 @default.
- W4239092428 hasConcept C2778820342 @default.
- W4239092428 hasConcept C28328180 @default.
- W4239092428 hasConcept C2910840531 @default.
- W4239092428 hasConcept C37307934 @default.
- W4239092428 hasConcept C42362537 @default.
- W4239092428 hasConcept C502942594 @default.
- W4239092428 hasConcept C54355233 @default.
- W4239092428 hasConcept C555283112 @default.
- W4239092428 hasConcept C62478195 @default.
- W4239092428 hasConcept C86803240 @default.
- W4239092428 hasConcept C95444343 @default.
- W4239092428 hasConceptScore W4239092428C101544691 @default.
- W4239092428 hasConceptScore W4239092428C104317684 @default.
- W4239092428 hasConceptScore W4239092428C109159458 @default.
- W4239092428 hasConceptScore W4239092428C121608353 @default.
- W4239092428 hasConceptScore W4239092428C145059251 @default.
- W4239092428 hasConceptScore W4239092428C16930146 @default.
- W4239092428 hasConceptScore W4239092428C2022786 @default.
- W4239092428 hasConceptScore W4239092428C2775922572 @default.
- W4239092428 hasConceptScore W4239092428C2777007597 @default.
- W4239092428 hasConceptScore W4239092428C2777583451 @default.
- W4239092428 hasConceptScore W4239092428C2778729363 @default.
- W4239092428 hasConceptScore W4239092428C2778820342 @default.
- W4239092428 hasConceptScore W4239092428C28328180 @default.
- W4239092428 hasConceptScore W4239092428C2910840531 @default.
- W4239092428 hasConceptScore W4239092428C37307934 @default.
- W4239092428 hasConceptScore W4239092428C42362537 @default.
- W4239092428 hasConceptScore W4239092428C502942594 @default.
- W4239092428 hasConceptScore W4239092428C54355233 @default.
- W4239092428 hasConceptScore W4239092428C555283112 @default.
- W4239092428 hasConceptScore W4239092428C62478195 @default.
- W4239092428 hasConceptScore W4239092428C86803240 @default.
- W4239092428 hasConceptScore W4239092428C95444343 @default.
- W4239092428 hasIssue "7" @default.
- W4239092428 hasLocation W42390924281 @default.
- W4239092428 hasOpenAccess W4239092428 @default.
- W4239092428 hasPrimaryLocation W42390924281 @default.
- W4239092428 hasRelatedWork W1996901086 @default.
- W4239092428 hasRelatedWork W2026386845 @default.
- W4239092428 hasRelatedWork W2039477457 @default.
- W4239092428 hasRelatedWork W2099252657 @default.
- W4239092428 hasRelatedWork W2108431450 @default.
- W4239092428 hasRelatedWork W2135874746 @default.
- W4239092428 hasRelatedWork W2140626630 @default.
- W4239092428 hasRelatedWork W2902072959 @default.
- W4239092428 hasRelatedWork W2903363945 @default.
- W4239092428 hasRelatedWork W4239092428 @default.
- W4239092428 hasVolume "19" @default.
- W4239092428 isParatext "false" @default.
- W4239092428 isRetracted "false" @default.
- W4239092428 workType "article" @default.