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- W4239136601 abstract "Objective To characterize the clinical features of patients with autoantibodies against dymple, a dynamin-related protein. Methods Serum samples from 281 patients with rheumatic diseases were examined. The characteristics of antidymple and antibody-reactive determinants were investigated by immunoblotting with the recombinant dymple antigen, including its deletion mutants, and by immunofluorescence studies with affinity-purified serum. Results Five serum samples (2%) were found to have antidymple. All of these patients were male, and 4 of them had interstitial pneumonitis. Their sera were considered to mainly recognize the N-terminus of dymple, which contains GTP-binding motifs. Conclusion Dymple, which joins the cytoplasmic autoantigens, could be a marker for a newly recognized subset of connective tissue diseases." @default.
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- W4239136601 date "2000-07-01" @default.
- W4239136601 modified "2023-10-18" @default.
- W4239136601 title "Spectrum of autoantibodies against a dynamin-related protein, dymple" @default.
- W4239136601 doi "https://doi.org/10.1002/1529-0131(200007)43:7<1516::aid-anr15>3.3.co;2-h" @default.
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