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- W4239184927 abstract "Effect of Nε-dansyI-l-lysine [Nε-(5-dimethylaminonaphthalenesulfonyl)-l-lysine] on amino acid transport across the brush border of isolated rat small intestine was investigated. Nε-Dansy-l-lysine was not actively accumulated nor transmurally transported by the intestinal tissue; nonetheless, it competitively inhibited the basic amino acid transport with a Ki of about 0.4 mm for l-lysine, but entirely not the neutral amino acid transport. The inhibition was relatively independent of extracellular Na+. The minimal dependence on Na+ parallels with the least Na+ dependence of lysine transport among various amino acid transport systems, suggesting the inhibition competes for a step involved in a heteroexchange process mediating the greater portion of lysine transport. The results provided a basis for a potential use of Nε-dansyl-l-lysine as a fluorescent probe in delineating its interaction with basic amino acid transport system in the small intestine." @default.
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- W4239184927 date "1977-01-01" @default.
- W4239184927 modified "2023-10-14" @default.
- W4239184927 title "Inhibition of Amino Acid Transport in Rat Small Intestine by Nε-Substitutedl-Lysine Derivatives" @default.
- W4239184927 doi "https://doi.org/10.1080/00021369.1977.10862458" @default.
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