Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239210159> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4239210159 abstract "Abstract Background Home parenteral nutrition (HPN) is a life-preserving therapy for patients with chronic intestinal failure (CIF) indicated for patients who cannot achieve their nutritional requirements by enteral intake. Intravenous lipid emulsions (ILEs) are an essential component of HPN providing energy and essential fatty acids, but can become a risk factor for intestinal failure-associated liver disease (IFALD). In HPN patients, major effort is taken in the prevention of IFALD. Novel ILEs containing a proportion of omega-3 polyunsaturated fatty acids (n-3 PUFA) could be of benefit, but the data on the use of n-3 PUFA in HPN patients are still limited.Methods The HOME study is a prospective, randomized, controlled, double-blind, multicenter, international clinical trial conducted in European hospitals that treat HPN patients. A total of 160 patients (80 per group) will be randomly assigned to receive the n-3 PUFA enriched medium/long-chain triglyceride (MCT/LCT) ILE (Lipidem / Lipoplus ® 200 mg/ml, B. Braun Melsungen AG) or the MCT/LCT ILE (Lipofundin ® MCT/LCT / Medialipide ® 20%, B. Braun Melsungen AG) for a projected period of eight weeks. The primary endpoint is the combined change of liver function parameters (total bilirubin, aspartate transaminase and alanine transaminase) from baseline to final visit. Secondary objectives are the further evaluation of safety and tolerability as well as the efficacy of the ILEs.Discussion Currently, there are only very few randomized controlled trials (RCTs) investigating the use of ILEs in HPN, and there are very few data at all on the use of n-3 PUFAs. The aim of the HOME study is to demonstrate that the n-3 PUFA enriched ILE is safe and well tolerated especially with regard to liver function in patients requiring HPN. The study will provide data from a considerable number of CIF patients and thus contribute to broaden the present evidence on the use of ILEs in HPN.Trial registrationClinicalTrials.gov, NCT03282955, registered on September 14, 2017" @default.
- W4239210159 created "2022-05-12" @default.
- W4239210159 creator A5000038754 @default.
- W4239210159 creator A5004386921 @default.
- W4239210159 creator A5014019436 @default.
- W4239210159 creator A5047169308 @default.
- W4239210159 creator A5051642332 @default.
- W4239210159 creator A5058686770 @default.
- W4239210159 creator A5058953953 @default.
- W4239210159 creator A5059049938 @default.
- W4239210159 creator A5066304291 @default.
- W4239210159 creator A5073023612 @default.
- W4239210159 creator A5080218882 @default.
- W4239210159 creator A5081536249 @default.
- W4239210159 creator A5088983987 @default.
- W4239210159 date "2019-09-26" @default.
- W4239210159 modified "2023-09-25" @default.
- W4239210159 title "Home parenteral nutrition with an omega-3 fatty acid enriched MCT/LCT lipid emulsion in patients with chronic intestinal failure (the HOME study): Study protocol for a randomized, controlled, multicenter, international clinical trial" @default.
- W4239210159 doi "https://doi.org/10.21203/rs.2.15196/v1" @default.
- W4239210159 hasPublicationYear "2019" @default.
- W4239210159 type Work @default.
- W4239210159 citedByCount "0" @default.
- W4239210159 crossrefType "posted-content" @default.
- W4239210159 hasAuthorship W4239210159A5000038754 @default.
- W4239210159 hasAuthorship W4239210159A5004386921 @default.
- W4239210159 hasAuthorship W4239210159A5014019436 @default.
- W4239210159 hasAuthorship W4239210159A5047169308 @default.
- W4239210159 hasAuthorship W4239210159A5051642332 @default.
- W4239210159 hasAuthorship W4239210159A5058686770 @default.
- W4239210159 hasAuthorship W4239210159A5058953953 @default.
- W4239210159 hasAuthorship W4239210159A5059049938 @default.
- W4239210159 hasAuthorship W4239210159A5066304291 @default.
- W4239210159 hasAuthorship W4239210159A5073023612 @default.
- W4239210159 hasAuthorship W4239210159A5080218882 @default.
- W4239210159 hasAuthorship W4239210159A5081536249 @default.
- W4239210159 hasAuthorship W4239210159A5088983987 @default.
- W4239210159 hasBestOaLocation W42392101591 @default.
- W4239210159 hasConcept C126322002 @default.
- W4239210159 hasConcept C168563851 @default.
- W4239210159 hasConcept C19038510 @default.
- W4239210159 hasConcept C197934379 @default.
- W4239210159 hasConcept C203092338 @default.
- W4239210159 hasConcept C2778375690 @default.
- W4239210159 hasConcept C2992208098 @default.
- W4239210159 hasConcept C44315111 @default.
- W4239210159 hasConcept C535046627 @default.
- W4239210159 hasConcept C543025807 @default.
- W4239210159 hasConcept C55493867 @default.
- W4239210159 hasConcept C71924100 @default.
- W4239210159 hasConcept C78722104 @default.
- W4239210159 hasConcept C86803240 @default.
- W4239210159 hasConcept C90924648 @default.
- W4239210159 hasConceptScore W4239210159C126322002 @default.
- W4239210159 hasConceptScore W4239210159C168563851 @default.
- W4239210159 hasConceptScore W4239210159C19038510 @default.
- W4239210159 hasConceptScore W4239210159C197934379 @default.
- W4239210159 hasConceptScore W4239210159C203092338 @default.
- W4239210159 hasConceptScore W4239210159C2778375690 @default.
- W4239210159 hasConceptScore W4239210159C2992208098 @default.
- W4239210159 hasConceptScore W4239210159C44315111 @default.
- W4239210159 hasConceptScore W4239210159C535046627 @default.
- W4239210159 hasConceptScore W4239210159C543025807 @default.
- W4239210159 hasConceptScore W4239210159C55493867 @default.
- W4239210159 hasConceptScore W4239210159C71924100 @default.
- W4239210159 hasConceptScore W4239210159C78722104 @default.
- W4239210159 hasConceptScore W4239210159C86803240 @default.
- W4239210159 hasConceptScore W4239210159C90924648 @default.
- W4239210159 hasLocation W42392101591 @default.
- W4239210159 hasLocation W42392101592 @default.
- W4239210159 hasLocation W42392101593 @default.
- W4239210159 hasLocation W42392101594 @default.
- W4239210159 hasLocation W42392101595 @default.
- W4239210159 hasLocation W42392101596 @default.
- W4239210159 hasOpenAccess W4239210159 @default.
- W4239210159 hasPrimaryLocation W42392101591 @default.
- W4239210159 hasRelatedWork W1556562895 @default.
- W4239210159 hasRelatedWork W1994194863 @default.
- W4239210159 hasRelatedWork W2000054321 @default.
- W4239210159 hasRelatedWork W2035634985 @default.
- W4239210159 hasRelatedWork W2107697672 @default.
- W4239210159 hasRelatedWork W2416506383 @default.
- W4239210159 hasRelatedWork W2502883985 @default.
- W4239210159 hasRelatedWork W2789023463 @default.
- W4239210159 hasRelatedWork W3031392606 @default.
- W4239210159 hasRelatedWork W3032602558 @default.
- W4239210159 isParatext "false" @default.
- W4239210159 isRetracted "false" @default.
- W4239210159 workType "article" @default.