Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239211603> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4239211603 endingPage "tw469" @default.
- W4239211603 startingPage "tw469" @default.
- W4239211603 abstract "Karnik et al. have obtained evidence suggesting that the extracellular matrix protein elastin acts as an autocrine regulator of vascular smooth muscle proliferation and migration, a finding that could have implications for the therapy of vascular proliferative diseases. Various vascular proliferative diseases, including atherosclerosis and coronary restenosis, are characterized by dedifferentiation, abnormal proliferation, and migration of vascular smooth muscle cells, a pathophysiological reaction to injury that has largely been interpreted as a response to cytokines released by inflammatory cells. By comparing vascular smooth muscle cells from mice lacking elastin to cells from wild-type sibling controls, Karnik et al. showed that that the extracellular matrix protein elastin, which is secreted by vascular smooth cells, inhibited cell proliferation and promoted the development of actin stress fibers, a marker for a mature contractile phenotype. Elastin influenced cell migration: vascular smooth muscle cells migrated through a filter in response to an elastin concentration gradient but elastin inhibited the cells' migration in response to a platelet-derived growth factor gradient. EDTA, which binds divalent cations thereby inhibiting integrin-mediated interactions, did not inhibit elastin's effects. Rather, pharmacological analysis indicated that elastin activates a guanosine triphosphate (GTP)-binding protein pathway involving a Gi-mediated reduction in cellular cyclic adenosine monophosphate and the stimulation of Rho. In an in vivo porcine model of coronary artery stenosis, insertion of an elastin sheath into arteries following vascular injury reduced the pathophysiological response, suggesting the possibility that elastin's effects on vascular smooth muscle could be exploited in the therapy of vascular proliferative diseases.S. K. Karnik, B. S. Brooke, A. Bayes-Genis, L. Sorensen, J. D. Wythe, R. S. Schwartz, M. T. Keating, D.Y. Li, A critical role for elastin signaling in vascular morphogenesis and disease. Development 130, 411-423 (2002). [Abstract] [Full Text]" @default.
- W4239211603 created "2022-05-12" @default.
- W4239211603 date "2002-12-17" @default.
- W4239211603 modified "2023-09-25" @default.
- W4239211603 title "Elastin Keeps Cells in Their Place" @default.
- W4239211603 doi "https://doi.org/10.1126/scisignal.1632002tw469" @default.
- W4239211603 hasPublicationYear "2002" @default.
- W4239211603 type Work @default.
- W4239211603 citedByCount "0" @default.
- W4239211603 crossrefType "journal-article" @default.
- W4239211603 hasConcept C134018914 @default.
- W4239211603 hasConcept C142724271 @default.
- W4239211603 hasConcept C185592680 @default.
- W4239211603 hasConcept C189165786 @default.
- W4239211603 hasConcept C2779395532 @default.
- W4239211603 hasConcept C2779869378 @default.
- W4239211603 hasConcept C2992686903 @default.
- W4239211603 hasConcept C71924100 @default.
- W4239211603 hasConcept C86803240 @default.
- W4239211603 hasConcept C95444343 @default.
- W4239211603 hasConcept C99322962 @default.
- W4239211603 hasConceptScore W4239211603C134018914 @default.
- W4239211603 hasConceptScore W4239211603C142724271 @default.
- W4239211603 hasConceptScore W4239211603C185592680 @default.
- W4239211603 hasConceptScore W4239211603C189165786 @default.
- W4239211603 hasConceptScore W4239211603C2779395532 @default.
- W4239211603 hasConceptScore W4239211603C2779869378 @default.
- W4239211603 hasConceptScore W4239211603C2992686903 @default.
- W4239211603 hasConceptScore W4239211603C71924100 @default.
- W4239211603 hasConceptScore W4239211603C86803240 @default.
- W4239211603 hasConceptScore W4239211603C95444343 @default.
- W4239211603 hasConceptScore W4239211603C99322962 @default.
- W4239211603 hasIssue "163" @default.
- W4239211603 hasLocation W42392116031 @default.
- W4239211603 hasOpenAccess W4239211603 @default.
- W4239211603 hasPrimaryLocation W42392116031 @default.
- W4239211603 hasRelatedWork W140314102 @default.
- W4239211603 hasRelatedWork W1967602390 @default.
- W4239211603 hasRelatedWork W1976913833 @default.
- W4239211603 hasRelatedWork W1991155818 @default.
- W4239211603 hasRelatedWork W2018088453 @default.
- W4239211603 hasRelatedWork W2052860570 @default.
- W4239211603 hasRelatedWork W2100371635 @default.
- W4239211603 hasRelatedWork W2325242309 @default.
- W4239211603 hasRelatedWork W2945932739 @default.
- W4239211603 hasRelatedWork W3174765302 @default.
- W4239211603 hasVolume "2002" @default.
- W4239211603 isParatext "false" @default.
- W4239211603 isRetracted "false" @default.
- W4239211603 workType "article" @default.