Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239291296> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4239291296 endingPage "1100" @default.
- W4239291296 startingPage "1092" @default.
- W4239291296 abstract "Defects within the oral mucosa can result from a variety of causes, including tumors and trauma. Adults have limited ability to regenerate after tissue loss or injury, meaning autografts to reconstruct defects are often required. Due to shortcomings associated to tissue transplantation, the use of tissue engineering technology to reconstruct and regenerate oral tissues has gained attention. In this regard, HAM (human amniotic membrane) was utilized as a biological material for tissue engineering applications. However, its unfavorable properties have limited its use, and hybrid scaffolds based on HAM have been investigated. Thus, in this study, a biomimetic hybrid scaffold composed of gelatin methacryloyl and decellularized human amniotic particles (GelMA-dHAP) was prepared and used as a tissue substitute to promote wound healing of the oral mucosa in rabbits. First, the degradation and swelling characteristics of the scaffold were evaluated and found to be more desirable than those of GelMA alone. Then, the effects of the GelMA-dHAP stent on the proliferation and differentiation of human foreskin fibroblasts were studied in vitro using a cell counting kit-8 (CCK8) and immunofluorescence, respectively. This showed that the hybrid scaffold could significantly promote fibroblast proliferation and differentiation in comparison to controls. Following these initial assessments and to better understand the underlying mechanism of wound healing, in vivo histological and immunohistochemical studies were undertaken using a rabbit oral mucosa defect model. The results showed that GelMA-dHAP can promote angiogenesis and collagen expression within the oral mucosa. Importantly, the GelMA-dHAP scaffold was shown to assist wound healing better than GelMA alone, demonstrating the potential of the hybrid scaffold in tissue engineering." @default.
- W4239291296 created "2022-05-12" @default.
- W4239291296 creator A5032848524 @default.
- W4239291296 creator A5039837606 @default.
- W4239291296 creator A5064125880 @default.
- W4239291296 creator A5074942308 @default.
- W4239291296 creator A5076237248 @default.
- W4239291296 creator A5083047932 @default.
- W4239291296 date "2021-07-01" @default.
- W4239291296 modified "2023-09-24" @default.
- W4239291296 title "Decellularized human amniotic particles reinforced with GelMA assist wound healing of the oral mucosa in vivo" @default.
- W4239291296 doi "https://doi.org/10.1166/mex.2021.2021" @default.
- W4239291296 hasPublicationYear "2021" @default.
- W4239291296 type Work @default.
- W4239291296 citedByCount "0" @default.
- W4239291296 crossrefType "journal-article" @default.
- W4239291296 hasAuthorship W4239291296A5032848524 @default.
- W4239291296 hasAuthorship W4239291296A5039837606 @default.
- W4239291296 hasAuthorship W4239291296A5064125880 @default.
- W4239291296 hasAuthorship W4239291296A5074942308 @default.
- W4239291296 hasAuthorship W4239291296A5076237248 @default.
- W4239291296 hasAuthorship W4239291296A5083047932 @default.
- W4239291296 hasConcept C136229726 @default.
- W4239291296 hasConcept C141071460 @default.
- W4239291296 hasConcept C142724271 @default.
- W4239291296 hasConcept C150903083 @default.
- W4239291296 hasConcept C185592680 @default.
- W4239291296 hasConcept C190672674 @default.
- W4239291296 hasConcept C192562407 @default.
- W4239291296 hasConcept C202751555 @default.
- W4239291296 hasConcept C207001950 @default.
- W4239291296 hasConcept C2779409057 @default.
- W4239291296 hasConcept C2780269544 @default.
- W4239291296 hasConcept C2780381497 @default.
- W4239291296 hasConcept C2780394083 @default.
- W4239291296 hasConcept C2781140480 @default.
- W4239291296 hasConcept C49892992 @default.
- W4239291296 hasConcept C502942594 @default.
- W4239291296 hasConcept C54355233 @default.
- W4239291296 hasConcept C55493867 @default.
- W4239291296 hasConcept C71924100 @default.
- W4239291296 hasConcept C81885089 @default.
- W4239291296 hasConcept C86803240 @default.
- W4239291296 hasConcept C89429830 @default.
- W4239291296 hasConceptScore W4239291296C136229726 @default.
- W4239291296 hasConceptScore W4239291296C141071460 @default.
- W4239291296 hasConceptScore W4239291296C142724271 @default.
- W4239291296 hasConceptScore W4239291296C150903083 @default.
- W4239291296 hasConceptScore W4239291296C185592680 @default.
- W4239291296 hasConceptScore W4239291296C190672674 @default.
- W4239291296 hasConceptScore W4239291296C192562407 @default.
- W4239291296 hasConceptScore W4239291296C202751555 @default.
- W4239291296 hasConceptScore W4239291296C207001950 @default.
- W4239291296 hasConceptScore W4239291296C2779409057 @default.
- W4239291296 hasConceptScore W4239291296C2780269544 @default.
- W4239291296 hasConceptScore W4239291296C2780381497 @default.
- W4239291296 hasConceptScore W4239291296C2780394083 @default.
- W4239291296 hasConceptScore W4239291296C2781140480 @default.
- W4239291296 hasConceptScore W4239291296C49892992 @default.
- W4239291296 hasConceptScore W4239291296C502942594 @default.
- W4239291296 hasConceptScore W4239291296C54355233 @default.
- W4239291296 hasConceptScore W4239291296C55493867 @default.
- W4239291296 hasConceptScore W4239291296C71924100 @default.
- W4239291296 hasConceptScore W4239291296C81885089 @default.
- W4239291296 hasConceptScore W4239291296C86803240 @default.
- W4239291296 hasConceptScore W4239291296C89429830 @default.
- W4239291296 hasIssue "7" @default.
- W4239291296 hasLocation W42392912961 @default.
- W4239291296 hasOpenAccess W4239291296 @default.
- W4239291296 hasPrimaryLocation W42392912961 @default.
- W4239291296 hasRelatedWork W1236521 @default.
- W4239291296 hasRelatedWork W20176976 @default.
- W4239291296 hasRelatedWork W24216105 @default.
- W4239291296 hasRelatedWork W33746831 @default.
- W4239291296 hasRelatedWork W34119873 @default.
- W4239291296 hasRelatedWork W37352985 @default.
- W4239291296 hasRelatedWork W418642 @default.
- W4239291296 hasRelatedWork W4296211 @default.
- W4239291296 hasRelatedWork W7233486 @default.
- W4239291296 hasRelatedWork W27779954 @default.
- W4239291296 hasVolume "11" @default.
- W4239291296 isParatext "false" @default.
- W4239291296 isRetracted "false" @default.
- W4239291296 workType "article" @default.