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- W4239302231 endingPage "22" @default.
- W4239302231 startingPage "5" @default.
- W4239302231 abstract "Diabetes induces functional and structural changes in the microvessels; these changes occur through multiple mechanisms and at multiple levels, and exert damaging consequences for the tissues. Structurally, the most notable changes induced by diabetes in the microvessels involve the decreased number and size of capillaries, and the increased thickness of the basement membrane. Functional changes are represented by the inability of the microvessels to modify their caliber in response to local stimuli; they can be the result of different conditions, such as: endothelial dysfunction, smooth muscle cell dysfunction, impairment of the nerve axon reflex, defective myogenic reflex, and reduced functional hyperemia. Indeed, endothelial dysfunction appears to play a pivotal role in the development of diabetic microangiopathy. In diabetes, the main causes of endothelial dysfunction have been postulated to include hyperglycemia – via mechanisms such as advanced glycosylated end products (AGEs), polyol pathway, oxidative stress, and protein kinase C (PKC), insulin resistance, and inflammation. In addition, the role of the immune system has gained increasing interest over the past few years, and it has been recently proposed that some immune subpopulations might protect microvessels against diabetes, in the context of diabetic leukostasis." @default.
- W4239302231 created "2022-05-12" @default.
- W4239302231 creator A5040889625 @default.
- W4239302231 date "2020-03-13" @default.
- W4239302231 modified "2023-10-12" @default.
- W4239302231 title "Pathophysiology" @default.
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