Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239304680> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4239304680 endingPage "943" @default.
- W4239304680 startingPage "932" @default.
- W4239304680 abstract "After spinal cord injury, enzymatic digestion of chondroitin sulfate proteoglycans promotes axonal regeneration of central nervous system neurons across the lesion scar. We examined whether chondroitinase ABC (ChABC) promotes the axonal regeneration of rubrospinal tract (RST) neurons following injury to the spinal cord. The effect of a GSK-3beta inhibitor, lithium chloride (LiCl), on the regeneration of axotomized RST neurons was also assessed. Adult rats received a unilateral hemisection at the seventh cervical spinal cord segment (C7). Four weeks after different treatments, regeneration of RST axons across the lesion scar was examined by injection of Fluoro-Gold at spinal segment T2, and locomotor recovery was studied by a test of forelimb usage. Injured RST axons did not regenerate spontaneously after spinal cord injury, and intraperitoneal injection of LiCl alone did not promote the regeneration of RST axons. Administration of ChABC at the lesion site enhanced the regeneration of RST axons by 20%. Combined treatment of LiCl together with ChABC significantly increased the regeneration of RST axons to 42%. Animals receiving combined treatment used both forelimbs together more often than animals that received sham or single treatment. Immunoblotting and immunohistochemical analysis revealed that LiCl induced the expression of inactive GSK-3beta as well as the upregulation of Bcl-2 in injured RST neurons. These results indicate that in vivo, LiCl inhibits GSK-3beta and reinforces the regeneration-promoting function of ChABC through a Bcl-2-dependent mechanism. Combined use of LiCl together with ChABC could be a novel treatment for spinal cord injury." @default.
- W4239304680 created "2022-05-12" @default.
- W4239304680 creator A5005434770 @default.
- W4239304680 creator A5043564867 @default.
- W4239304680 creator A5074186579 @default.
- W4239304680 creator A5080932213 @default.
- W4239304680 date "2004-07-01" @default.
- W4239304680 modified "2023-09-27" @default.
- W4239304680 title "Lithium Chloride Reinforces the Regeneration-Promoting Effect of Chondroitinase ABC on Rubrospinal Neurons after Spinal Cord Injury" @default.
- W4239304680 doi "https://doi.org/10.1089/neu.2004.21.932" @default.
- W4239304680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15307905" @default.
- W4239304680 hasPublicationYear "2004" @default.
- W4239304680 type Work @default.
- W4239304680 citedByCount "21" @default.
- W4239304680 countsByYear W42393046802014 @default.
- W4239304680 countsByYear W42393046802015 @default.
- W4239304680 countsByYear W42393046802016 @default.
- W4239304680 countsByYear W42393046802017 @default.
- W4239304680 countsByYear W42393046802018 @default.
- W4239304680 countsByYear W42393046802019 @default.
- W4239304680 countsByYear W42393046802022 @default.
- W4239304680 countsByYear W42393046802023 @default.
- W4239304680 crossrefType "journal-article" @default.
- W4239304680 hasAuthorship W4239304680A5005434770 @default.
- W4239304680 hasAuthorship W4239304680A5043564867 @default.
- W4239304680 hasAuthorship W4239304680A5074186579 @default.
- W4239304680 hasAuthorship W4239304680A5080932213 @default.
- W4239304680 hasBestOaLocation W42393046802 @default.
- W4239304680 hasConcept C105702510 @default.
- W4239304680 hasConcept C142724271 @default.
- W4239304680 hasConcept C169760540 @default.
- W4239304680 hasConcept C171056886 @default.
- W4239304680 hasConcept C178790620 @default.
- W4239304680 hasConcept C185592680 @default.
- W4239304680 hasConcept C25498285 @default.
- W4239304680 hasConcept C2777594495 @default.
- W4239304680 hasConcept C2778334475 @default.
- W4239304680 hasConcept C2778646069 @default.
- W4239304680 hasConcept C2779530196 @default.
- W4239304680 hasConcept C2780775167 @default.
- W4239304680 hasConcept C2780990938 @default.
- W4239304680 hasConcept C2781156865 @default.
- W4239304680 hasConcept C529278444 @default.
- W4239304680 hasConcept C71924100 @default.
- W4239304680 hasConcept C86803240 @default.
- W4239304680 hasConcept C95444343 @default.
- W4239304680 hasConceptScore W4239304680C105702510 @default.
- W4239304680 hasConceptScore W4239304680C142724271 @default.
- W4239304680 hasConceptScore W4239304680C169760540 @default.
- W4239304680 hasConceptScore W4239304680C171056886 @default.
- W4239304680 hasConceptScore W4239304680C178790620 @default.
- W4239304680 hasConceptScore W4239304680C185592680 @default.
- W4239304680 hasConceptScore W4239304680C25498285 @default.
- W4239304680 hasConceptScore W4239304680C2777594495 @default.
- W4239304680 hasConceptScore W4239304680C2778334475 @default.
- W4239304680 hasConceptScore W4239304680C2778646069 @default.
- W4239304680 hasConceptScore W4239304680C2779530196 @default.
- W4239304680 hasConceptScore W4239304680C2780775167 @default.
- W4239304680 hasConceptScore W4239304680C2780990938 @default.
- W4239304680 hasConceptScore W4239304680C2781156865 @default.
- W4239304680 hasConceptScore W4239304680C529278444 @default.
- W4239304680 hasConceptScore W4239304680C71924100 @default.
- W4239304680 hasConceptScore W4239304680C86803240 @default.
- W4239304680 hasConceptScore W4239304680C95444343 @default.
- W4239304680 hasIssue "7" @default.
- W4239304680 hasLocation W42393046801 @default.
- W4239304680 hasLocation W42393046802 @default.
- W4239304680 hasLocation W42393046803 @default.
- W4239304680 hasOpenAccess W4239304680 @default.
- W4239304680 hasPrimaryLocation W42393046801 @default.
- W4239304680 hasRelatedWork W1969118134 @default.
- W4239304680 hasRelatedWork W2093814006 @default.
- W4239304680 hasRelatedWork W2095263564 @default.
- W4239304680 hasRelatedWork W2147149841 @default.
- W4239304680 hasRelatedWork W2259113178 @default.
- W4239304680 hasRelatedWork W2416027765 @default.
- W4239304680 hasRelatedWork W2531862582 @default.
- W4239304680 hasRelatedWork W2794169559 @default.
- W4239304680 hasRelatedWork W2806854514 @default.
- W4239304680 hasRelatedWork W4309039855 @default.
- W4239304680 hasVolume "21" @default.
- W4239304680 isParatext "false" @default.
- W4239304680 isRetracted "false" @default.
- W4239304680 workType "article" @default.