FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239308523> ?p ?o ?g. }

• W4239308523 endingPage "5167" @default.
• W4239308523 startingPage "5159" @default.
• W4239308523 abstract "Little is known about the transcriptional events which occur downstream of polyadenylation sites. Although the polyadenylation site of a gene can be easily identified, it has been difficult to determine the site of transcription termination in vivo because of the rapid processing of pre-mRNAs. Using an in vitro approach, we have shown that sequences from the 3' ends of two different Saccharomyces cerevisiae genes, ADH2 and GAL7, direct transcription termination and/or polymerase pausing in yeast nuclear extracts. In the case of the ADH2 sequence, the RNA synthesized in vitro ends approximately 50 to 150 nucleotides downstream of the poly(A) site. This RNA is not polyadenylated and may represent the primary transcript. A similarly sized nonpolyadenylated [poly(A)-] transcript can be detected in vivo from the same transcriptional template. A GAL7 template also directs the in vitro synthesis of an RNA which extends a short distance past the poly(A) site. However, a significant amount of the GAL7 RNA is polyadenylated at or close to the in vivo poly(A) site. Mutations of GAL7 or ADH2 poly(A) signals prevent polyadenylation but do not affect the in vitro synthesis of the extended poly(A)- transcript. Since transcription of the mutant template continues through this region in vivo, it is likely that a strong RNA polymerase II pause site lies within the 3'-end sequences. Our data support the hypothesis that the coupling of this pause site to a functional polyadenylation signal results in transcription termination." @default.
• W4239308523 created "2022-05-12" @default.
• W4239308523 creator A5029319648 @default.
• W4239308523 creator A5054452522 @default.
• W4239308523 date "1993-09-01" @default.
• W4239308523 modified "2023-09-25" @default.
• W4239308523 title "Termination and pausing of RNA polymerase II downstream of yeast polyadenylation sites" @default.
• W4239308523 cites W103796718 @default.
• W4239308523 cites W1533478806 @default.
• W4239308523 cites W1592978800 @default.
• W4239308523 cites W167755924 @default.
• W4239308523 cites W1931859177 @default.
• W4239308523 cites W1967814744 @default.
• W4239308523 cites W1977347668 @default.
• W4239308523 cites W1983276757 @default.
• W4239308523 cites W1990429873 @default.
• W4239308523 cites W1993725313 @default.
• W4239308523 cites W1995391727 @default.
• W4239308523 cites W1997911454 @default.
• W4239308523 cites W2001174263 @default.
• W4239308523 cites W2004635090 @default.
• W4239308523 cites W2012958702 @default.
• W4239308523 cites W2020070631 @default.
• W4239308523 cites W2026137624 @default.
• W4239308523 cites W2029560063 @default.
• W4239308523 cites W2037852650 @default.
• W4239308523 cites W2069056849 @default.
• W4239308523 cites W2074613690 @default.
• W4239308523 cites W2083951909 @default.
• W4239308523 cites W2091423718 @default.
• W4239308523 cites W2094911787 @default.
• W4239308523 cites W2129131697 @default.
• W4239308523 cites W2143488845 @default.
• W4239308523 cites W293091720 @default.
• W4239308523 cites W295724713 @default.
• W4239308523 doi "https://doi.org/10.1128/mcb.13.9.5159-5167.1993" @default.
• W4239308523 hasPublicationYear "1993" @default.
• W4239308523 type Work @default.
• W4239308523 citedByCount "4" @default.
• W4239308523 crossrefType "journal-article" @default.
• W4239308523 hasAuthorship W4239308523A5029319648 @default.
• W4239308523 hasAuthorship W4239308523A5054452522 @default.
• W4239308523 hasConcept C101762097 @default.
• W4239308523 hasConcept C104317684 @default.
• W4239308523 hasConcept C116403925 @default.
• W4239308523 hasConcept C121332964 @default.
• W4239308523 hasConcept C1276947 @default.
• W4239308523 hasConcept C138885662 @default.
• W4239308523 hasConcept C142575336 @default.
• W4239308523 hasConcept C150194340 @default.
• W4239308523 hasConcept C153911025 @default.
• W4239308523 hasConcept C178046730 @default.
• W4239308523 hasConcept C179926584 @default.
• W4239308523 hasConcept C22232683 @default.
• W4239308523 hasConcept C2776449523 @default.
• W4239308523 hasConcept C41258723 @default.
• W4239308523 hasConcept C41895202 @default.
• W4239308523 hasConcept C42943712 @default.
• W4239308523 hasConcept C51807208 @default.
• W4239308523 hasConcept C54355233 @default.
• W4239308523 hasConcept C64350747 @default.
• W4239308523 hasConcept C67705224 @default.
• W4239308523 hasConcept C86803240 @default.
• W4239308523 hasConcept C95444343 @default.
• W4239308523 hasConceptScore W4239308523C101762097 @default.
• W4239308523 hasConceptScore W4239308523C104317684 @default.
• W4239308523 hasConceptScore W4239308523C116403925 @default.
• W4239308523 hasConceptScore W4239308523C121332964 @default.
• W4239308523 hasConceptScore W4239308523C1276947 @default.
• W4239308523 hasConceptScore W4239308523C138885662 @default.
• W4239308523 hasConceptScore W4239308523C142575336 @default.
• W4239308523 hasConceptScore W4239308523C150194340 @default.
• W4239308523 hasConceptScore W4239308523C153911025 @default.
• W4239308523 hasConceptScore W4239308523C178046730 @default.
• W4239308523 hasConceptScore W4239308523C179926584 @default.
• W4239308523 hasConceptScore W4239308523C22232683 @default.
• W4239308523 hasConceptScore W4239308523C2776449523 @default.
• W4239308523 hasConceptScore W4239308523C41258723 @default.
• W4239308523 hasConceptScore W4239308523C41895202 @default.
• W4239308523 hasConceptScore W4239308523C42943712 @default.
• W4239308523 hasConceptScore W4239308523C51807208 @default.
• W4239308523 hasConceptScore W4239308523C54355233 @default.
• W4239308523 hasConceptScore W4239308523C64350747 @default.
• W4239308523 hasConceptScore W4239308523C67705224 @default.
• W4239308523 hasConceptScore W4239308523C86803240 @default.
• W4239308523 hasConceptScore W4239308523C95444343 @default.
• W4239308523 hasIssue "9" @default.
• W4239308523 hasLocation W42393085231 @default.
• W4239308523 hasOpenAccess W4239308523 @default.
• W4239308523 hasPrimaryLocation W42393085231 @default.
• W4239308523 hasRelatedWork W1555221542 @default.
• W4239308523 hasRelatedWork W1799149248 @default.
• W4239308523 hasRelatedWork W2040237899 @default.
• W4239308523 hasRelatedWork W2105138293 @default.
• W4239308523 hasRelatedWork W2106760776 @default.
• W4239308523 hasRelatedWork W2228648677 @default.
• W4239308523 hasRelatedWork W2287064474 @default.
• W4239308523 hasRelatedWork W3118427689 @default.

• next