Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239364883> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4239364883 endingPage "87" @default.
- W4239364883 startingPage "83" @default.
- W4239364883 abstract "An adjuvant is an agent that may stimulate the immune system and increase the response to a vaccine, without having any specific antigenic effect itself. They are predominantly derived from pathogens and often represent pathogen-associated molecular patterns (PAMP) such as LPS, MPL, CpG DNA, bacterial polysaccharide (PS) antigens, bacterial capsular polysaccharide (CPS) conjugates, saponins-QS-21, cytokines, cholera toxin, synthetic oligonucleotides, alum, E. coli heat labile enterotoxin, IL-2, IL-12, GMCSF, lipopeptides, hormones, monophosphoryl lipid A, muramyldipeptide (MDP), T cell-epitope, and vaccine delivery systems such as emulsions, iscoms, liposomes, and microparticles. They activate the cells of the innate immune system. Once activated, the cells of innate immunity drive and focus the acquired immune response. In some studies, delivery systems and immunostimulatory agents have been combined for more effective delivery of the immunostimulatory adjuvant into the antigen-presenting cells (APC). The use of an adjuvant is crucial in rendering the vaccine able to induce an immune response. The use of adjuvant is usually required to induce strong immunological responses to protein antigen. However, serious side effects preclude their use in human vaccines. Currently, the only adjuvant that is licensed for use in human vaccines is an alum. Red blood cells (RBC) can be used as an antigen delivery system for the enhancement of immune targeting for vaccination purposes. Vaccination remains the single most valuable tool in the prevention of infectious disease. Nevertheless, there exists a need to improve the performance of existing vaccines such that fewer boosters are needed or to develop novel vaccines. For the development of effective vaccines for humans, a great need exists for safe and effective adjuvants." @default.
- W4239364883 created "2022-05-12" @default.
- W4239364883 creator A5004422727 @default.
- W4239364883 date "2021-01-01" @default.
- W4239364883 modified "2023-10-16" @default.
- W4239364883 title "Adjuvants" @default.
- W4239364883 cites W1482954238 @default.
- W4239364883 cites W1775774657 @default.
- W4239364883 cites W1973487069 @default.
- W4239364883 cites W1982835519 @default.
- W4239364883 cites W1985190174 @default.
- W4239364883 cites W2006263441 @default.
- W4239364883 cites W2017976051 @default.
- W4239364883 cites W2019255983 @default.
- W4239364883 cites W2051079195 @default.
- W4239364883 cites W2059433996 @default.
- W4239364883 cites W2059956370 @default.
- W4239364883 cites W2071118518 @default.
- W4239364883 cites W2077061106 @default.
- W4239364883 cites W2086967479 @default.
- W4239364883 cites W2087930487 @default.
- W4239364883 cites W2118738201 @default.
- W4239364883 cites W2144887013 @default.
- W4239364883 cites W2396263072 @default.
- W4239364883 cites W2415087928 @default.
- W4239364883 cites W3037133185 @default.
- W4239364883 cites W97562825 @default.
- W4239364883 doi "https://doi.org/10.1016/b978-0-323-91124-5.00005-9" @default.
- W4239364883 hasPublicationYear "2021" @default.
- W4239364883 type Work @default.
- W4239364883 citedByCount "0" @default.
- W4239364883 crossrefType "book-chapter" @default.
- W4239364883 hasAuthorship W4239364883A5004422727 @default.
- W4239364883 hasConcept C136449434 @default.
- W4239364883 hasConcept C147483822 @default.
- W4239364883 hasConcept C203014093 @default.
- W4239364883 hasConcept C2777863537 @default.
- W4239364883 hasConcept C86803240 @default.
- W4239364883 hasConcept C8891405 @default.
- W4239364883 hasConcept C89423630 @default.
- W4239364883 hasConceptScore W4239364883C136449434 @default.
- W4239364883 hasConceptScore W4239364883C147483822 @default.
- W4239364883 hasConceptScore W4239364883C203014093 @default.
- W4239364883 hasConceptScore W4239364883C2777863537 @default.
- W4239364883 hasConceptScore W4239364883C86803240 @default.
- W4239364883 hasConceptScore W4239364883C8891405 @default.
- W4239364883 hasConceptScore W4239364883C89423630 @default.
- W4239364883 hasLocation W42393648831 @default.
- W4239364883 hasOpenAccess W4239364883 @default.
- W4239364883 hasPrimaryLocation W42393648831 @default.
- W4239364883 hasRelatedWork W1203091402 @default.
- W4239364883 hasRelatedWork W1993025569 @default.
- W4239364883 hasRelatedWork W2087047282 @default.
- W4239364883 hasRelatedWork W2093242067 @default.
- W4239364883 hasRelatedWork W2095304551 @default.
- W4239364883 hasRelatedWork W2220102944 @default.
- W4239364883 hasRelatedWork W2411712784 @default.
- W4239364883 hasRelatedWork W2478440915 @default.
- W4239364883 hasRelatedWork W3109192410 @default.
- W4239364883 hasRelatedWork W276659083 @default.
- W4239364883 isParatext "false" @default.
- W4239364883 isRetracted "false" @default.
- W4239364883 workType "book-chapter" @default.