Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239382015> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4239382015 abstract "A failure in self-tolerance leads to autoimmune destruction of pancreatic β-cells and type 1 diabetes (T1D). Low molecular weight dextran sulfate (DS) is a sulfated semi-synthetic polysaccharide with demonstrated cytoprotective and immunomodulatory properties <i>in vitro</i>. However, whether DS can protect pancreatic β-cells, reduce autoimmunity and ameliorate T1D is unknown. Here we report that DS, but not dextran, protects human β-cells against cytokine-mediated cytotoxicity <i>in vitro</i>. DS also protects mitochondrial function and glucose-stimulated insulin secretion and reduces chemokine expression in human islets in a pro-inflammatory environment. Interestingly, daily treatment with DS significantly reduces diabetes incidence in pre-diabetic non-obese diabetic (NOD) mice, and most importantly, reverses diabetes in early-onset diabetic NOD mice. DS decreases β-cell death, enhances islet heparan sulfate (HS)/heparan sulfate proteoglycan (HSPG) expression and preserves β-cell mass and plasma insulin in these mice. DS administration also increases the expression of the inhibitory co-stimulatory molecule programmed death-1 (PD-1) in T-cells, reduces interferon-γ+ CD4+ and CD8+ T-cells and enhances the number of FoxP3+ cells. Collectively, these studies demonstrate that the action of one single molecule, DS, on β-cell protection, extracellular matrix preservation and immunomodulation can reverse diabetes in NOD mice highlighting its therapeutic potential for the treatment of T1D." @default.
- W4239382015 created "2022-05-12" @default.
- W4239382015 creator A5001602213 @default.
- W4239382015 creator A5003433077 @default.
- W4239382015 creator A5006140692 @default.
- W4239382015 creator A5020374655 @default.
- W4239382015 creator A5032424732 @default.
- W4239382015 creator A5032992689 @default.
- W4239382015 creator A5035624729 @default.
- W4239382015 creator A5049316377 @default.
- W4239382015 creator A5052123970 @default.
- W4239382015 creator A5062204706 @default.
- W4239382015 creator A5080873078 @default.
- W4239382015 creator A5082640552 @default.
- W4239382015 creator A5084171262 @default.
- W4239382015 creator A5087762808 @default.
- W4239382015 date "2020-05-07" @default.
- W4239382015 modified "2023-10-18" @default.
- W4239382015 title "Dextran Sulfate Protects Pancreatic β-Cells, Reduces Autoimmunity and Ameliorates Type 1 Diabetes" @default.
- W4239382015 doi "https://doi.org/10.2337/figshare.12245363.v1" @default.
- W4239382015 hasPublicationYear "2020" @default.
- W4239382015 type Work @default.
- W4239382015 citedByCount "0" @default.
- W4239382015 crossrefType "posted-content" @default.
- W4239382015 hasAuthorship W4239382015A5001602213 @default.
- W4239382015 hasAuthorship W4239382015A5003433077 @default.
- W4239382015 hasAuthorship W4239382015A5006140692 @default.
- W4239382015 hasAuthorship W4239382015A5020374655 @default.
- W4239382015 hasAuthorship W4239382015A5032424732 @default.
- W4239382015 hasAuthorship W4239382015A5032992689 @default.
- W4239382015 hasAuthorship W4239382015A5035624729 @default.
- W4239382015 hasAuthorship W4239382015A5049316377 @default.
- W4239382015 hasAuthorship W4239382015A5052123970 @default.
- W4239382015 hasAuthorship W4239382015A5062204706 @default.
- W4239382015 hasAuthorship W4239382015A5080873078 @default.
- W4239382015 hasAuthorship W4239382015A5082640552 @default.
- W4239382015 hasAuthorship W4239382015A5084171262 @default.
- W4239382015 hasAuthorship W4239382015A5087762808 @default.
- W4239382015 hasBestOaLocation W42393820151 @default.
- W4239382015 hasConcept C126322002 @default.
- W4239382015 hasConcept C13373296 @default.
- W4239382015 hasConcept C134018914 @default.
- W4239382015 hasConcept C165220095 @default.
- W4239382015 hasConcept C185592680 @default.
- W4239382015 hasConcept C203014093 @default.
- W4239382015 hasConcept C2778013207 @default.
- W4239382015 hasConcept C2779727006 @default.
- W4239382015 hasConcept C2779855799 @default.
- W4239382015 hasConcept C2780130043 @default.
- W4239382015 hasConcept C555293320 @default.
- W4239382015 hasConcept C55851684 @default.
- W4239382015 hasConcept C71924100 @default.
- W4239382015 hasConcept C86803240 @default.
- W4239382015 hasConcept C8891405 @default.
- W4239382015 hasConceptScore W4239382015C126322002 @default.
- W4239382015 hasConceptScore W4239382015C13373296 @default.
- W4239382015 hasConceptScore W4239382015C134018914 @default.
- W4239382015 hasConceptScore W4239382015C165220095 @default.
- W4239382015 hasConceptScore W4239382015C185592680 @default.
- W4239382015 hasConceptScore W4239382015C203014093 @default.
- W4239382015 hasConceptScore W4239382015C2778013207 @default.
- W4239382015 hasConceptScore W4239382015C2779727006 @default.
- W4239382015 hasConceptScore W4239382015C2779855799 @default.
- W4239382015 hasConceptScore W4239382015C2780130043 @default.
- W4239382015 hasConceptScore W4239382015C555293320 @default.
- W4239382015 hasConceptScore W4239382015C55851684 @default.
- W4239382015 hasConceptScore W4239382015C71924100 @default.
- W4239382015 hasConceptScore W4239382015C86803240 @default.
- W4239382015 hasConceptScore W4239382015C8891405 @default.
- W4239382015 hasLocation W42393820151 @default.
- W4239382015 hasOpenAccess W4239382015 @default.
- W4239382015 hasPrimaryLocation W42393820151 @default.
- W4239382015 hasRelatedWork W12239369 @default.
- W4239382015 hasRelatedWork W1282632 @default.
- W4239382015 hasRelatedWork W13152147 @default.
- W4239382015 hasRelatedWork W14411207 @default.
- W4239382015 hasRelatedWork W17572923 @default.
- W4239382015 hasRelatedWork W18378557 @default.
- W4239382015 hasRelatedWork W2564165 @default.
- W4239382015 hasRelatedWork W6539829 @default.
- W4239382015 hasRelatedWork W8994981 @default.
- W4239382015 hasRelatedWork W1799632 @default.
- W4239382015 isParatext "false" @default.
- W4239382015 isRetracted "false" @default.
- W4239382015 workType "article" @default.