FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239410725> ?p ?o ?g. }

• W4239410725 endingPage "R140" @default.
• W4239410725 startingPage "R139" @default.
• W4239410725 abstract "What is Neurospora? Neurospora is the genus of a group of filamentous fungi but the word is most often used as a nickname for the best studied species, N. crassa, which has served as a model eukaryotic organism for nearly a century. The name Neurospora apparently came from the nerve-like stripes found on its sexual spores (‘ascospores’; Figure 1). Neurospora is easily recognizable by its orange aerial asexual spores (‘conidia’). What is its life style? The haploid vegetative filaments (‘hyphae’), which look somewhat like axons (Figure 2), weave together to form a mat (‘mycelium’). Neurospora grows at a prodigious rate — the mycelium advances at ∼4 mm per hour in a reasonably warm environment if given some sugar, simple nutrients, and one vitamin (biotin). N. crassa is ‘heterothallic’ meaning that it has different subtypes (‘mating types’) that must find each other to enter the sexual phase of the life cycle. About 10 days later, its fruiting bodies (‘perithecia’) shoot the ascospores towards light. Germination of ascospores requires heat (for example, 65°C for an hour), which kills other cells in the neighborhood and accounts for reports of Neurospora in French bakeries in the 1800s and for the presence of Neurospora in burned sugar cane fields and burned forests in modern times. What was Neurospora first known for? Research in the 1920s and 1930s revealed N. crassa to be a convenient and powerful genetic system; indeed it became a textbook example of first-division and second-division segregation, with easily demonstrable crossing over at the four-strand stage, and provided the first proof of gene conversion. The fact that it could be easily grown on defined media led to its adoption for the Nobel-prize winning ‘one gene–one enzyme’ work of Beadle and Tatum in the 1940s, which demonstrated that genes control biochemical processes. This and similar studies established the field of biochemical genetics and effectively initiated the discipline now known as molecular biology. Since then, Neurospora has served as a useful model in a large number of studies on problems in biochemistry, genetics, cell biology, development, physiology and population genetics, generally predating similar work with bacteria, yeasts, Drosophila, worms, mice, plants and other model systems. Why is Neurospora still a favored model organism? Although Escherichia coli and yeast ultimately became more popular than Neurospora for studying many basic problems in molecular biology and genetics, Neurospora offers features not found in these and other eukaryotic systems. Thus, Neurospora is still regarded as an exemplary system for numerous genetic and molecular studies. Some of the reasons that it is an excellent model organism are: 1. Neurospora is easy to grow (in either liquid or solidified medium) and to store in suspended animation; 2. the haploid vegetative tissue is handy for scoring genetic traits and generating heterokaryons (strains with genetically distinct nuclei), useful for complementation tests; 3. Neurospora's rapid and well-defined sexual cycle, compact genome with small, but cytologically recognizable, chromosomes that can be readily modified using either classical or molecular techniques makes the organism well-suited for genetic studies; 4. thousands of genes/mutations have been characterized and a high-quality genome sequence is available; 5. extensive collections of wild and constructed strains are readily obtainable, including knock-out mutants for the majority of known and predicted genes; 6. Neurospora sports features of higher eukaryotes that are absent from many other simple systems, for example DNA methylation and other ‘epigenetic’ marks, photobiology, circadian rhythms, gene silencing systems, cytoplasmic streaming, vegetative incompatibility reactions, morphogenesis; 7. modern tools are available for Neurospora, such as materials and methods to silence genes, to introduce genes at either homologous or non-homologous genomic sites and to perform proteomic studies; 8. the Neurospora community is unusually friendly and cooperative. It is noteworthy that a few talented, dedicated and altruistic Neurospora researchers, including the late David Perkins and the late Bob Metzenberg, were instrumental in publicizing the virtues of Neurospora while demonstrating that the use of Neurospora as a model system can be highly productive and fun. Neurospora meetings, which take place at Asilomar conference grounds in even years, typically draw 150–200 participants and welcome newcomers. Can you tell me something wild about Neurospora? Starting with the discovery of ‘repeat-induced point mutation’ (RIP) more than two decades ago, Neurospora has revealed several remarkable and unexpected genetic mechanisms that serve to counter invasive DNA. RIP, which operates in the sexual phase of the life cycle in the period between fertilization and nuclear fusion, scans the haploid genome for duplicated sequences, such as those commonly resulting from the activity of transposable elements. Such sequences are then inactivated with multiple C to T mutations as well as with methylation of remaining cytosines. In addition, in vegetative cells, repeated sequences commonly generate aberrant RNAs that trigger silencing via an RNA interference (RNAi) mechanism called ‘quelling’. Finally, in meiosis, unpaired sequences, such as those resulting from insertions or deletions in one parent, cause temporary silencing by another RNAi-based mechanism known as ‘meiotic silencing by unpaired DNA’ (MSUD)." @default.
• W4239410725 created "2022-05-12" @default.
• W4239410725 creator A5034497861 @default.
• W4239410725 date "2011-02-01" @default.
• W4239410725 modified "2023-09-29" @default.
• W4239410725 title "Neurospora" @default.
• W4239410725 cites W1521664071 @default.
• W4239410725 cites W1964021638 @default.
• W4239410725 cites W2080766885 @default.
• W4239410725 cites W2167493116 @default.
• W4239410725 cites W40091365 @default.
• W4239410725 doi "https://doi.org/10.1016/j.cub.2011.01.006" @default.
• W4239410725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21334288" @default.
• W4239410725 hasPublicationYear "2011" @default.
• W4239410725 type Work @default.
• W4239410725 citedByCount "14" @default.
• W4239410725 countsByYear W42394107252012 @default.
• W4239410725 countsByYear W42394107252014 @default.
• W4239410725 countsByYear W42394107252015 @default.
• W4239410725 countsByYear W42394107252017 @default.
• W4239410725 countsByYear W42394107252018 @default.
• W4239410725 countsByYear W42394107252019 @default.
• W4239410725 countsByYear W42394107252020 @default.
• W4239410725 countsByYear W42394107252021 @default.
• W4239410725 countsByYear W42394107252022 @default.
• W4239410725 crossrefType "journal-article" @default.
• W4239410725 hasAuthorship W4239410725A5034497861 @default.
• W4239410725 hasBestOaLocation W42394107251 @default.
• W4239410725 hasConcept C104317684 @default.
• W4239410725 hasConcept C133479454 @default.
• W4239410725 hasConcept C143065580 @default.
• W4239410725 hasConcept C174618031 @default.
• W4239410725 hasConcept C187489309 @default.
• W4239410725 hasConcept C198348125 @default.
• W4239410725 hasConcept C2776739539 @default.
• W4239410725 hasConcept C2776769606 @default.
• W4239410725 hasConcept C2777251434 @default.
• W4239410725 hasConcept C43143990 @default.
• W4239410725 hasConcept C54355233 @default.
• W4239410725 hasConcept C59822182 @default.
• W4239410725 hasConcept C86803240 @default.
• W4239410725 hasConceptScore W4239410725C104317684 @default.
• W4239410725 hasConceptScore W4239410725C133479454 @default.
• W4239410725 hasConceptScore W4239410725C143065580 @default.
• W4239410725 hasConceptScore W4239410725C174618031 @default.
• W4239410725 hasConceptScore W4239410725C187489309 @default.
• W4239410725 hasConceptScore W4239410725C198348125 @default.
• W4239410725 hasConceptScore W4239410725C2776739539 @default.
• W4239410725 hasConceptScore W4239410725C2776769606 @default.
• W4239410725 hasConceptScore W4239410725C2777251434 @default.
• W4239410725 hasConceptScore W4239410725C43143990 @default.
• W4239410725 hasConceptScore W4239410725C54355233 @default.
• W4239410725 hasConceptScore W4239410725C59822182 @default.
• W4239410725 hasConceptScore W4239410725C86803240 @default.
• W4239410725 hasIssue "4" @default.
• W4239410725 hasLocation W42394107251 @default.
• W4239410725 hasLocation W42394107252 @default.
• W4239410725 hasOpenAccess W4239410725 @default.
• W4239410725 hasPrimaryLocation W42394107251 @default.
• W4239410725 hasRelatedWork W1499965780 @default.
• W4239410725 hasRelatedWork W1952898995 @default.
• W4239410725 hasRelatedWork W1997801720 @default.
• W4239410725 hasRelatedWork W2000943360 @default.
• W4239410725 hasRelatedWork W2003442364 @default.
• W4239410725 hasRelatedWork W2014382618 @default.
• W4239410725 hasRelatedWork W2033719072 @default.
• W4239410725 hasRelatedWork W2053695989 @default.
• W4239410725 hasRelatedWork W2080465737 @default.
• W4239410725 hasRelatedWork W2323342569 @default.
• W4239410725 hasVolume "21" @default.
• W4239410725 isParatext "false" @default.
• W4239410725 isRetracted "false" @default.
• W4239410725 workType "article" @default.