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- W4239415057 abstract "Abstract Background: Postoperative pain is a serious clinical problem with a poorly understood mechanism and lack of effective treatment. Considering hydrogen (H 2 ) could reduce neuroinflammation, we hypothesizes that hydrogen may alleviate postoperative pain and investigate the mechanism. Methods: Mice were used to establish postoperative pain model via performing a plantar incision surgery. Mechanical allodynia was measured using the Von Frey test. Cell signaling was assayed using gelatin zymography, western blotting, immunohistochemistry and immunofluorescence staining. The animals or BV-2 cells were received with/without ASK1 and Trx1 inhibitor to investigate the effects of H 2 on microglia. Results: Plantar incision surgery significantly decreased the mechanical threshold, and increased MMP-9 activity and ASK1 phosphorylation in the spinal cord of mice. MMP-9 knockout and ASK1 inhibitor NQDI-1 attenuated postoperative pain. H 2 treatment increased Trx1 expression, decreased ASK1, p38 and JNK phosphorylation, MMP-9 activity, pro-IL-1β maturation and IBA-1 expression in the spinal cord of postoperative pain mice, and ameliorated postoperative pain. In vitro, H 2 increased Trx1 expression and reduced MMP-9 activity induced by LPS in BV-2 cells. Additionally, H 2 also reduced ASK1, p38 and JNK phosphorylation, and IBA-1 expression induced by LPS, which were abolished by Trx1 inhibitor PX12 in BV-2 cells. Conclusions: For the first time the results confirm that H 2 can work as a therapeutic agent for ameliorating postoperative pain through Trx1/ASK1/MMP9 signaling pathway. MMP-9 and ASK1 may be the targeting molecules to relieve postoperative pain." @default.
- W4239415057 created "2022-05-12" @default.
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- W4239415057 date "2020-01-24" @default.
- W4239415057 modified "2023-09-29" @default.
- W4239415057 title "Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway" @default.
- W4239415057 doi "https://doi.org/10.21203/rs.2.21716/v1" @default.
- W4239415057 hasPublicationYear "2020" @default.
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