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• W4239436013 endingPage "S47" @default.
• W4239436013 startingPage "S41" @default.
• W4239436013 abstract "The aim of the present paper is to review the various aspects of refractory schizophrenia regarding issues such as definitions, clinical aspects, psychobiological correlates, pharmacological and non-pharmacological treatment options and predictors of treatment response.Medline search as well as articles of the authors.Refractory schizophrenia affects at least one third of patients with schizophrenia and the best evidence shows that is monotherapy with clozapine remains the mainstay for the treatment of such condition. Antipsychotic polipharmacy is not supported by current evidence and recent clinical trials have shown that clozapine augmentation with antipsychotics has no benefit over placebo." @default.
• W4239436013 created "2022-05-12" @default.
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• W4239436013 date "2007-10-01" @default.
• W4239436013 modified "2023-10-05" @default.
• W4239436013 title "Esquizofrenia refratária" @default.
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• W4239436013 doi "https://doi.org/10.1590/s1516-44462007000600002" @default.
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