Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239458432> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4239458432 endingPage "xi" @default.
- W4239458432 startingPage "xi" @default.
- W4239458432 abstract "Hypertensive disorders of pregnancy continue to be amongst the leading causes of maternal morbidity and mortality. There is debate about the optimal monitoring and treatment for these women, particularly in regard to circulatory and fluid management. A restrictive fluid strategy is advocated, which conflicts with the prevailing view that the circulating volume is contracted in pre-eclampsia. This belief has been erroneously reinforced by use of the central venous pressure (CVP) as a measure of the volume state.We used a Guytonian model of the circulation involving the mean systemic filling pressure (Pms) to review published data using a cohort of normal pregnant/post partum women and a pre-eclamptic cohort. The Pms is the pressure left in the circulation when the heart is stopped, arguably the true volume state measure. An analogue of the Pms (Pmsa) can be calculated using commonly measured haemodynamic variables.Our results show the Pmsa to be elevated in normal pregnancy versus post partum (10.79 vs. 9.58, a 12.6% difference) and elevated further in pre-eclamptic pregnancy (13.86, 29% higher than the normal pregnant group).There is scope to challenge the long held belief that the volume state is contracted in pre-eclampsia. This approach indicates that the maternal volume state in pre-eclampsia is often elevated. When viewed in combination with recent echocardiographic insights this model helps to explain some of the haemodynamic management paradoxes that these women present. Most importantly, it provides a sound physiological basis for the restrictive fluid strategy that is currently recommended." @default.
- W4239458432 created "2022-05-12" @default.
- W4239458432 creator A5035149579 @default.
- W4239458432 date "1997-05-01" @default.
- W4239458432 modified "2023-10-16" @default.
- W4239458432 title "FOREWORD" @default.
- W4239458432 doi "https://doi.org/10.1016/s0733-8651(05)70326-x" @default.
- W4239458432 hasPublicationYear "1997" @default.
- W4239458432 type Work @default.
- W4239458432 citedByCount "0" @default.
- W4239458432 crossrefType "journal-article" @default.
- W4239458432 hasAuthorship W4239458432A5035149579 @default.
- W4239458432 hasConcept C126322002 @default.
- W4239458432 hasConcept C131872663 @default.
- W4239458432 hasConcept C159382316 @default.
- W4239458432 hasConcept C164705383 @default.
- W4239458432 hasConcept C178853913 @default.
- W4239458432 hasConcept C195646399 @default.
- W4239458432 hasConcept C2777953023 @default.
- W4239458432 hasConcept C2779234561 @default.
- W4239458432 hasConcept C2781276381 @default.
- W4239458432 hasConcept C35207712 @default.
- W4239458432 hasConcept C54355233 @default.
- W4239458432 hasConcept C71924100 @default.
- W4239458432 hasConcept C72563966 @default.
- W4239458432 hasConcept C84393581 @default.
- W4239458432 hasConcept C86803240 @default.
- W4239458432 hasConceptScore W4239458432C126322002 @default.
- W4239458432 hasConceptScore W4239458432C131872663 @default.
- W4239458432 hasConceptScore W4239458432C159382316 @default.
- W4239458432 hasConceptScore W4239458432C164705383 @default.
- W4239458432 hasConceptScore W4239458432C178853913 @default.
- W4239458432 hasConceptScore W4239458432C195646399 @default.
- W4239458432 hasConceptScore W4239458432C2777953023 @default.
- W4239458432 hasConceptScore W4239458432C2779234561 @default.
- W4239458432 hasConceptScore W4239458432C2781276381 @default.
- W4239458432 hasConceptScore W4239458432C35207712 @default.
- W4239458432 hasConceptScore W4239458432C54355233 @default.
- W4239458432 hasConceptScore W4239458432C71924100 @default.
- W4239458432 hasConceptScore W4239458432C72563966 @default.
- W4239458432 hasConceptScore W4239458432C84393581 @default.
- W4239458432 hasConceptScore W4239458432C86803240 @default.
- W4239458432 hasIssue "2" @default.
- W4239458432 hasLocation W42394584321 @default.
- W4239458432 hasOpenAccess W4239458432 @default.
- W4239458432 hasPrimaryLocation W42394584321 @default.
- W4239458432 hasRelatedWork W141768147 @default.
- W4239458432 hasRelatedWork W1993079004 @default.
- W4239458432 hasRelatedWork W2001631557 @default.
- W4239458432 hasRelatedWork W2043432888 @default.
- W4239458432 hasRelatedWork W2085417875 @default.
- W4239458432 hasRelatedWork W2156131652 @default.
- W4239458432 hasRelatedWork W2363400180 @default.
- W4239458432 hasRelatedWork W2925161737 @default.
- W4239458432 hasRelatedWork W3025055033 @default.
- W4239458432 hasRelatedWork W2585928343 @default.
- W4239458432 hasVolume "15" @default.
- W4239458432 isParatext "false" @default.
- W4239458432 isRetracted "false" @default.
- W4239458432 workType "article" @default.