Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239509962> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4239509962 endingPage "119" @default.
- W4239509962 startingPage "113" @default.
- W4239509962 abstract "A vaccine targeting sperm is an interesting approach to contraception. The acceptability of a sperm antigen for contraceptive vaccine development is contingent upon its sperm-specificity, surface expression for antibody binding, and involvement in fertilization. Sperm-zona pellucida (ZP) binding is a pivotal step and constitutes an attractive site for immunointerception. Using phage display technology, we have identified a novel dodecamer peptide sequence, designated as YLP12, that is present on sperm, and is involved in ZP binding and sperm capacitation/acrosome reaction in man/mouse. Extensive search in the human and mouse genome sequence databases did not indicate a complete identity with the YLP12nucleotide sequence. It is peptide mimetic with sperm receptor carbohydrate mimicking action that is involved in oocyte binding. The sperm-specific YLP12sequence is also involved in involuntary immunoinfertility in men, indicating its autoantigenicity, sperm-specificity, and involvement in fertility/infertility in humans. Vaccination of female animals with synthetic YLP12peptide causes a long-term reversible contraception by raising a sperm-specific immune response. The contraceptive effect could also be completely reversed voluntarily at any time by immunoneutralization of antibodies using intravaginal administration of the peptide. Thus, the novel synthetic YLP12peptide is an attractive candidate for contraceptive vaccine development, and diagnosis and treatment of immunoinfertility in humans." @default.
- W4239509962 created "2022-05-12" @default.
- W4239509962 creator A5032262345 @default.
- W4239509962 date "2004-01-01" @default.
- W4239509962 modified "2023-09-26" @default.
- W4239509962 title "HUMAN SYNTHETIC PEPTIDE VACCINE FOR CONTRACEPTION TARGETING SPERM" @default.
- W4239509962 cites W1481794779 @default.
- W4239509962 cites W1975781181 @default.
- W4239509962 cites W1975821522 @default.
- W4239509962 cites W1987880248 @default.
- W4239509962 cites W1995277973 @default.
- W4239509962 cites W2001706663 @default.
- W4239509962 cites W2009668604 @default.
- W4239509962 cites W2043198395 @default.
- W4239509962 cites W2064703499 @default.
- W4239509962 cites W2078976297 @default.
- W4239509962 cites W2102966272 @default.
- W4239509962 cites W2105299356 @default.
- W4239509962 cites W2124072977 @default.
- W4239509962 cites W2124477598 @default.
- W4239509962 cites W2125785701 @default.
- W4239509962 cites W2138368013 @default.
- W4239509962 cites W2151772071 @default.
- W4239509962 cites W2164835119 @default.
- W4239509962 cites W2182859426 @default.
- W4239509962 cites W2187543765 @default.
- W4239509962 cites W2276520622 @default.
- W4239509962 doi "https://doi.org/10.1080/aan.50.2.113.119" @default.
- W4239509962 hasPublicationYear "2004" @default.
- W4239509962 type Work @default.
- W4239509962 citedByCount "6" @default.
- W4239509962 countsByYear W42395099622012 @default.
- W4239509962 countsByYear W42395099622017 @default.
- W4239509962 countsByYear W42395099622019 @default.
- W4239509962 crossrefType "journal-article" @default.
- W4239509962 hasAuthorship W4239509962A5032262345 @default.
- W4239509962 hasBestOaLocation W42395099621 @default.
- W4239509962 hasConcept C159654299 @default.
- W4239509962 hasConcept C16685009 @default.
- W4239509962 hasConcept C195616568 @default.
- W4239509962 hasConcept C196843134 @default.
- W4239509962 hasConcept C203014093 @default.
- W4239509962 hasConcept C2776010925 @default.
- W4239509962 hasConcept C2776690073 @default.
- W4239509962 hasConcept C2776789287 @default.
- W4239509962 hasConcept C2779076696 @default.
- W4239509962 hasConcept C2779995066 @default.
- W4239509962 hasConcept C2780099242 @default.
- W4239509962 hasConcept C2780301668 @default.
- W4239509962 hasConcept C2781087480 @default.
- W4239509962 hasConcept C2908647359 @default.
- W4239509962 hasConcept C2986817661 @default.
- W4239509962 hasConcept C54355233 @default.
- W4239509962 hasConcept C71924100 @default.
- W4239509962 hasConcept C86803240 @default.
- W4239509962 hasConcept C99454951 @default.
- W4239509962 hasConceptScore W4239509962C159654299 @default.
- W4239509962 hasConceptScore W4239509962C16685009 @default.
- W4239509962 hasConceptScore W4239509962C195616568 @default.
- W4239509962 hasConceptScore W4239509962C196843134 @default.
- W4239509962 hasConceptScore W4239509962C203014093 @default.
- W4239509962 hasConceptScore W4239509962C2776010925 @default.
- W4239509962 hasConceptScore W4239509962C2776690073 @default.
- W4239509962 hasConceptScore W4239509962C2776789287 @default.
- W4239509962 hasConceptScore W4239509962C2779076696 @default.
- W4239509962 hasConceptScore W4239509962C2779995066 @default.
- W4239509962 hasConceptScore W4239509962C2780099242 @default.
- W4239509962 hasConceptScore W4239509962C2780301668 @default.
- W4239509962 hasConceptScore W4239509962C2781087480 @default.
- W4239509962 hasConceptScore W4239509962C2908647359 @default.
- W4239509962 hasConceptScore W4239509962C2986817661 @default.
- W4239509962 hasConceptScore W4239509962C54355233 @default.
- W4239509962 hasConceptScore W4239509962C71924100 @default.
- W4239509962 hasConceptScore W4239509962C86803240 @default.
- W4239509962 hasConceptScore W4239509962C99454951 @default.
- W4239509962 hasIssue "2" @default.
- W4239509962 hasLocation W42395099621 @default.
- W4239509962 hasOpenAccess W4239509962 @default.
- W4239509962 hasPrimaryLocation W42395099621 @default.
- W4239509962 hasRelatedWork W1974648953 @default.
- W4239509962 hasRelatedWork W1981118879 @default.
- W4239509962 hasRelatedWork W2026938951 @default.
- W4239509962 hasRelatedWork W2040884289 @default.
- W4239509962 hasRelatedWork W2064703499 @default.
- W4239509962 hasRelatedWork W2082352611 @default.
- W4239509962 hasRelatedWork W2110563434 @default.
- W4239509962 hasRelatedWork W2146064639 @default.
- W4239509962 hasRelatedWork W2389729039 @default.
- W4239509962 hasRelatedWork W2792374798 @default.
- W4239509962 hasVolume "50" @default.
- W4239509962 isParatext "false" @default.
- W4239509962 isRetracted "false" @default.
- W4239509962 workType "article" @default.