Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239594443> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4239594443 endingPage "350" @default.
- W4239594443 startingPage "339" @default.
- W4239594443 abstract "Occipitofrontal circumference (OFC) is one of the few physical findings in autism that varies significantly from the norm and is distinct and measurable. As part of a study of genetic heterogeneity of autism, we scrutinized data from a large sample of patients with idiopathic autism (N = 137), using OFC as the categorizing variable. The OFC standard deviation (OFCSD) values of the autistic propositi (0.61 ± 1.6) varied significantly from that of the normal population (0.0 ± 1.0), (P < 0.001). Comparison of the macrocephalic (OFCSD ≥ 2.0, N = 32) with the normocephalic individuals (−2 SD < OFCSD < +2 SD, N = 95) showed no significant differences in sex ratio, morphological status, IQ, seizure prevalence, or recurrence risks. The macrocephalic individuals were slightly less apt than those with normocephaly to have a family history of Attention Deficit Hyperactivity Disorder (ADHD) (P < 0.05). Each clinical subgroup of autism propositi, defined on the basis of phenotypic status, type of onset, seizure history, or IQ, had a higher than normal mean OFC indicating that macrocephaly is an independent clinical trait in autism. As in the non-autistic population, macrocephaly was highly familial with 45% of the macrocephalic and 37% of the normocephalic propositi having at least one macrocephalic parent. Microcephaly, however, was an independent significant variable that predicted the presence of other phenotypic or genetic traits and outcome. The microcephalic patients were more likely to have abnormal physical morphology, structural brain malformations, lower IQ, and seizures. Their sex ratio was closer to normal, and their relatives had a higher incidence of seizures. Am. J. Med. Genet. 95:339–350, 2000. © 2000 Wiley-Liss, Inc." @default.
- W4239594443 created "2022-05-12" @default.
- W4239594443 creator A5009617512 @default.
- W4239594443 creator A5024696003 @default.
- W4239594443 creator A5078807617 @default.
- W4239594443 creator A5087972203 @default.
- W4239594443 date "2000-12-11" @default.
- W4239594443 modified "2023-09-27" @default.
- W4239594443 title "Head circumference is an independent clinical finding associated with autism" @default.
- W4239594443 doi "https://doi.org/10.1002/1096-8628(20001211)95:4<339::aid-ajmg9>3.3.co;2-2" @default.
- W4239594443 hasPublicationYear "2000" @default.
- W4239594443 type Work @default.
- W4239594443 citedByCount "2" @default.
- W4239594443 crossrefType "journal-article" @default.
- W4239594443 hasAuthorship W4239594443A5009617512 @default.
- W4239594443 hasAuthorship W4239594443A5024696003 @default.
- W4239594443 hasAuthorship W4239594443A5078807617 @default.
- W4239594443 hasAuthorship W4239594443A5087972203 @default.
- W4239594443 hasBestOaLocation W42395944431 @default.
- W4239594443 hasConcept C118552586 @default.
- W4239594443 hasConcept C126322002 @default.
- W4239594443 hasConcept C166047926 @default.
- W4239594443 hasConcept C169900460 @default.
- W4239594443 hasConcept C187212893 @default.
- W4239594443 hasConcept C205778803 @default.
- W4239594443 hasConcept C2776395126 @default.
- W4239594443 hasConcept C2778376644 @default.
- W4239594443 hasConcept C2778538070 @default.
- W4239594443 hasConcept C2778594975 @default.
- W4239594443 hasConcept C2779234561 @default.
- W4239594443 hasConcept C2781083543 @default.
- W4239594443 hasConcept C2781179581 @default.
- W4239594443 hasConcept C2908647359 @default.
- W4239594443 hasConcept C3020057088 @default.
- W4239594443 hasConcept C54355233 @default.
- W4239594443 hasConcept C71924100 @default.
- W4239594443 hasConcept C86803240 @default.
- W4239594443 hasConcept C99454951 @default.
- W4239594443 hasConceptScore W4239594443C118552586 @default.
- W4239594443 hasConceptScore W4239594443C126322002 @default.
- W4239594443 hasConceptScore W4239594443C166047926 @default.
- W4239594443 hasConceptScore W4239594443C169900460 @default.
- W4239594443 hasConceptScore W4239594443C187212893 @default.
- W4239594443 hasConceptScore W4239594443C205778803 @default.
- W4239594443 hasConceptScore W4239594443C2776395126 @default.
- W4239594443 hasConceptScore W4239594443C2778376644 @default.
- W4239594443 hasConceptScore W4239594443C2778538070 @default.
- W4239594443 hasConceptScore W4239594443C2778594975 @default.
- W4239594443 hasConceptScore W4239594443C2779234561 @default.
- W4239594443 hasConceptScore W4239594443C2781083543 @default.
- W4239594443 hasConceptScore W4239594443C2781179581 @default.
- W4239594443 hasConceptScore W4239594443C2908647359 @default.
- W4239594443 hasConceptScore W4239594443C3020057088 @default.
- W4239594443 hasConceptScore W4239594443C54355233 @default.
- W4239594443 hasConceptScore W4239594443C71924100 @default.
- W4239594443 hasConceptScore W4239594443C86803240 @default.
- W4239594443 hasConceptScore W4239594443C99454951 @default.
- W4239594443 hasIssue "4" @default.
- W4239594443 hasLocation W42395944431 @default.
- W4239594443 hasOpenAccess W4239594443 @default.
- W4239594443 hasPrimaryLocation W42395944431 @default.
- W4239594443 hasRelatedWork W1517391732 @default.
- W4239594443 hasRelatedWork W1964214369 @default.
- W4239594443 hasRelatedWork W2029064689 @default.
- W4239594443 hasRelatedWork W2045277366 @default.
- W4239594443 hasRelatedWork W2049173423 @default.
- W4239594443 hasRelatedWork W2106495617 @default.
- W4239594443 hasRelatedWork W2157553871 @default.
- W4239594443 hasRelatedWork W3095904161 @default.
- W4239594443 hasRelatedWork W4239594443 @default.
- W4239594443 hasRelatedWork W4246507764 @default.
- W4239594443 hasVolume "95" @default.
- W4239594443 isParatext "false" @default.
- W4239594443 isRetracted "false" @default.
- W4239594443 workType "article" @default.