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- W4239608022 endingPage "1388" @default.
- W4239608022 startingPage "1373" @default.
- W4239608022 abstract "An important antibiotic target, DNA gyrase is an essential bacterial enzyme that introduces negative supercoils into DNA and relaxes positive supercoils accumulating in front of moving DNA and RNA polymerases. By altering the superhelical density, gyrase may regulate expression of bacterial genes. The information about how gyrase is distributed along genomic DNA and whether its distribution is affected by drugs is scarce. During catalysis, gyrase cleaves both DNA strands forming a covalently bound intermediate. By exploiting the ability of several topoisomerase poisons to stabilize this intermediate we developed a ChIP-Seq-based approach to locate, with single nucleotide resolution, DNA gyrase cleavage sites (GCSs) throughout the Escherichia coli genome. We identified an extended gyrase binding motif with phased 10-bp G/C content variation, indicating that bending ability of DNA contributes to gyrase binding. We also found that GCSs are enriched in extended regions located downstream of highly transcribed operons. Transcription inhibition leads to redistribution of gyrase suggesting that the enrichment is functionally significant. Our method can be applied for precise mapping of prokaryotic and eukaryotic type II topoisomerases cleavage sites in a variety of organisms and paves the way for future studies of various topoisomerase inhibitors." @default.
- W4239608022 created "2022-05-12" @default.
- W4239608022 creator A5006247345 @default.
- W4239608022 creator A5012345482 @default.
- W4239608022 creator A5033657711 @default.
- W4239608022 creator A5056880626 @default.
- W4239608022 creator A5083187060 @default.
- W4239608022 date "2018-12-04" @default.
- W4239608022 modified "2023-10-16" @default.
- W4239608022 title "Single-nucleotide-resolution mapping of DNA gyrase cleavage sites across the<i>Escherichia coli</i>genome" @default.
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