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- W4239626714 abstract "This chapter discusses several hypnosedatives and anxiolytics and their side effects. Insomnia is a common and distressing condition caused by a range of physical, psychological, and physiological factors. Drugs such as tricyclic antidepressants can be suggested, because of their sedative effects and low risk of dependence, but they should be avoided because of their adverse effects profile, including cardiotoxicity. However, benzodiazepines continue to be widely used for the treatment of insomnia. Among older individuals, the use of benzodiazepines slightly increased the risk of fracture of the femur. Overall, non-oxidative benzodiazepines do not seem to confer a lower risk than oxidative agents. However, the latter may be more dangerous among very old individuals. Treatment with alprazolam can also result in behavioral disinhibition. Lesopitron is a non-benzodiazepine anxiolytic drug. Its structure is similar to that of buspirone, and it is an agonist at central serotonin receptors. The most common adverse events with lesopitron were somnolence, head ache, and dyspepsia, compared with headache, somnolence, and insomnia with lorazepam. Patients treated with placebo mainly experienced headache, somnolence, and pharyngitis." @default.
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- W4239626714 date "2000-12-01" @default.
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- W4239626714 title "Effects of a controlled challenge of chloral hydrate in pneumatosis cystoides coli—further evidence of a causal link?" @default.
- W4239626714 doi "https://doi.org/10.1016/s0002-9270(00)02190-0" @default.
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