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- W4239683320 abstract "A progressive increase of complications of type 2 DM makes the problem very important for clinical andfundamental medicine. In particular, neurodegenerative processes in case of type 2 DM aggravate the courseof the disease, change a usual life rhythm, and are a valuable cause of high rates of disability and lethality.Deterioration of cognitive functions is one of the main complications of diabetes. In certain literary sourcesinhibitors of angiotensin-transforming enzyme are considered as the means to prevent and treat complicationsof diabetes mellitus. Their role as modulators of gama-aminobutyric acid with development of central diabeticneurodegeneration is not completely determined yet.Therefore, the objective of the study is to assess efficacy of pharmacological correction of cognitive disordersby carbacetam, a GABA modulator, and enalapril, a RAS blocker, in case of experimental neurodegenerationcaused by type 2 DM.Changes of the cognitive functions under carbacetam and enalapril effect in nonlinear laboratory albinomale rats with neural degeneration under conditions of type 2 diabetes mellitus simulated by streptozotocin andhigh fat diet are studied. The cognitive ability was assessed by behavioral reactions of rats in the tests «openfield» and «the conditional reflex reaction of passive avoidance» by Butler formula.Behavior of rats with type 2 diabetes mellitus after administration of carbacetam and enalapril showed ofcognitive functions in the groups. At the same time, carbacetam was found to possess better correcting effect onadaptation, cognitive reactions and anti-amnestic activity, while enalapril improved emotional condition of therats mostly. Analysis of anti-amnestic properties found higher values of the parameters on the 14th day than onthe 1st day of correction, which is indicative of the efficacy of a course administration of carbacetam and enalapril under conditions of neural degeneration stipulated by type 2 DM." @default.
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- W4239683320 date "2019-11-11" @default.
- W4239683320 modified "2023-09-26" @default.
- W4239683320 title "PHARMACOLOGICAL CORRECTION OF COGNITIVE DISORDERS IN EXPERIMENTAL NEURODEGENERATION CAUSED BY 2 TYPE DIABETES MELLITUS*" @default.
- W4239683320 doi "https://doi.org/10.21856/j-pep.2019.4.07" @default.
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