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- W4239754019 abstract "Brain metastases affect up to 34% of breast cancer patients treated with trastuzumab (1). Limited treatment options are available for clinical control of brain metastatic breast cancer (2-4). We mined published microarray data (5, 6) to identify genes associated with metastasis to the brain in human breast cancer. This unbiased, global gene expression analysis identified differential expression of sulfatase 1, encoded by SULF1, as a transcriptional feature of brain metastasis in patients with breast cancer. We recently identified heparan sulfate proteoglycan 2, HSPG2, as among the genes most differentially expressed when comparing brain metastases to primary tumors of the breast (7). Thus, a heparan sulfate proteoglycan and an enzyme that catalyzes sulfation of heparan sulfate proteoglycans (8) are both among the genes whose expression differs most significantly transcirptome-wide between primary tumors of the breast and brain metastases in patients with metastatic breast cancer." @default.
- W4239754019 created "2022-05-12" @default.
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- W4239754019 date "2020-12-02" @default.
- W4239754019 modified "2023-10-18" @default.
- W4239754019 title "Sulfatase 1 is differentially expressed in brain metastatic breast cancer." @default.
- W4239754019 doi "https://doi.org/10.31219/osf.io/g5prw" @default.
- W4239754019 hasPublicationYear "2020" @default.
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