Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239757918> ?p ?o ?g. }
- W4239757918 abstract "We studied the molecular evolution of the capsid gene in all genotypes (genotypes 1-9) of human norovirus (NoV) genogroup I. The evolutionary time scale and rate were estimated by the Bayesian Markov chain Monte Carlo (MCMC) method. We also performed selective pressure analysis and B-cell linear epitope prediction in the deduced NoV GI capsid protein. Furthermore, we analysed the effective population size of the virus using Bayesian skyline plot (BSP) analysis. A phylogenetic tree by MCMC showed that NoV GI diverged from the common ancestor of NoV GII, GIII, and GIV approximately 2,800 years ago with rapid evolution (about 10(-3) substitutions/site/year). Some positive selection sites and over 400 negative selection sites were estimated in the deduced capsid protein. Many epitopes were estimated in the deduced virus capsid proteins. An epitope of GI.1 may be associated with histo-blood group antigen binding sites (Ser377, Pro378, and Ser380). Moreover, BSP suggested that the adaptation of NoV GI strains to humans was affected by natural selection. The results suggested that NoV GI strains evolved rapidly and date back to many years ago. Additionally, the virus may have undergone locally affected natural selection in the host resulting in its adaptation to humans." @default.
- W4239757918 created "2022-05-12" @default.
- W4239757918 creator A5000312467 @default.
- W4239757918 creator A5003078115 @default.
- W4239757918 creator A5015763821 @default.
- W4239757918 creator A5019233921 @default.
- W4239757918 creator A5028859845 @default.
- W4239757918 creator A5038782760 @default.
- W4239757918 creator A5042333728 @default.
- W4239757918 creator A5044603246 @default.
- W4239757918 creator A5059944889 @default.
- W4239757918 creator A5062642490 @default.
- W4239757918 creator A5062710592 @default.
- W4239757918 creator A5064305413 @default.
- W4239757918 creator A5070913984 @default.
- W4239757918 creator A5077509974 @default.
- W4239757918 creator A5081761804 @default.
- W4239757918 creator A5082384826 @default.
- W4239757918 creator A5082492405 @default.
- W4239757918 creator A5082687357 @default.
- W4239757918 creator A5087660349 @default.
- W4239757918 creator A5091763458 @default.
- W4239757918 creator A5091878292 @default.
- W4239757918 date "2015-09-04" @default.
- W4239757918 modified "2023-10-16" @default.
- W4239757918 title "Molecular Evolution of the Capsid Gene in Norovirus Genogroup I" @default.
- W4239757918 cites W1577051069 @default.
- W4239757918 cites W1971304145 @default.
- W4239757918 cites W1974116969 @default.
- W4239757918 cites W1982020294 @default.
- W4239757918 cites W1985635427 @default.
- W4239757918 cites W1985684734 @default.
- W4239757918 cites W1988686801 @default.
- W4239757918 cites W1990430932 @default.
- W4239757918 cites W1996423252 @default.
- W4239757918 cites W2001762003 @default.
- W4239757918 cites W2010118921 @default.
- W4239757918 cites W2011323609 @default.
- W4239757918 cites W2013479934 @default.
- W4239757918 cites W2022983554 @default.
- W4239757918 cites W2025109096 @default.
- W4239757918 cites W2028464135 @default.
- W4239757918 cites W2035014358 @default.
- W4239757918 cites W2046001565 @default.
- W4239757918 cites W2060907336 @default.
- W4239757918 cites W2065309989 @default.
- W4239757918 cites W2066128679 @default.
- W4239757918 cites W2069870355 @default.
- W4239757918 cites W2072974935 @default.
- W4239757918 cites W2073434299 @default.
- W4239757918 cites W2079005064 @default.
- W4239757918 cites W2081681634 @default.
- W4239757918 cites W2085264483 @default.
- W4239757918 cites W2089638478 @default.
- W4239757918 cites W2091139850 @default.
- W4239757918 cites W2093527644 @default.
- W4239757918 cites W2094206246 @default.
- W4239757918 cites W2095815056 @default.
- W4239757918 cites W2110835349 @default.
- W4239757918 cites W2116668053 @default.
- W4239757918 cites W2118943119 @default.
- W4239757918 cites W2118982822 @default.
- W4239757918 cites W2121960517 @default.
- W4239757918 cites W2130788389 @default.
- W4239757918 cites W2135821507 @default.
- W4239757918 cites W2136847298 @default.
- W4239757918 cites W2137015675 @default.
- W4239757918 cites W2147710356 @default.
- W4239757918 cites W2152207030 @default.
- W4239757918 cites W2157947651 @default.
- W4239757918 cites W2158605925 @default.
- W4239757918 cites W2160397907 @default.
- W4239757918 cites W2462282361 @default.
- W4239757918 cites W2591717879 @default.
- W4239757918 cites W4211177544 @default.
- W4239757918 doi "https://doi.org/10.1038/srep13806" @default.
- W4239757918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26338545" @default.
- W4239757918 hasPublicationYear "2015" @default.
- W4239757918 type Work @default.
- W4239757918 citedByCount "21" @default.
- W4239757918 countsByYear W42397579182016 @default.
- W4239757918 countsByYear W42397579182017 @default.
- W4239757918 countsByYear W42397579182018 @default.
- W4239757918 countsByYear W42397579182019 @default.
- W4239757918 countsByYear W42397579182020 @default.
- W4239757918 countsByYear W42397579182022 @default.
- W4239757918 countsByYear W42397579182023 @default.
- W4239757918 crossrefType "journal-article" @default.
- W4239757918 hasAuthorship W4239757918A5000312467 @default.
- W4239757918 hasAuthorship W4239757918A5003078115 @default.
- W4239757918 hasAuthorship W4239757918A5015763821 @default.
- W4239757918 hasAuthorship W4239757918A5019233921 @default.
- W4239757918 hasAuthorship W4239757918A5028859845 @default.
- W4239757918 hasAuthorship W4239757918A5038782760 @default.
- W4239757918 hasAuthorship W4239757918A5042333728 @default.
- W4239757918 hasAuthorship W4239757918A5044603246 @default.
- W4239757918 hasAuthorship W4239757918A5059944889 @default.
- W4239757918 hasAuthorship W4239757918A5062642490 @default.
- W4239757918 hasAuthorship W4239757918A5062710592 @default.
- W4239757918 hasAuthorship W4239757918A5064305413 @default.