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- W4239759297 abstract "Oral et al (N Engl J Med 2006;354:934) conducted a randomized, controlled trial of circumferential pulmonary vein (PV) ablation for treatment of chronic atrial fibrillation (AF). The authors randomly assigned 146 patients to receive amiodarone and undergo two cardioversions during the first 3 months alone (the control group) or in combination with circumferential PV ablation. Among the 77 patients assigned to undergo circumferential PV ablation, ablation was repeated because of recurrent AF in 26% of patients and atypical atrial flutter in 6%. An intention-to-treat analysis showed that 74% of patients in the ablation group and 58% of those in the control group were free of recurrent AF or flutter without antiarrhythmic drug therapy at 1 year (P = .05). Among the 69 patients in the control group, 53 (77%) crossed over to undergo circumferential PV ablation for recurrent AF by 1 year and only 3 (4%) were in sinus rhythm without antiarrhythmic drug therapy or ablation. The authors conclude that sinus rhythm can be maintained in the long term in the majority of patients with chronic AF by means of circumferential PV ablation independent of the effects of antiarrhythmic drug therapy, cardioversion, or both. Maintenance of sinus rhythm is associated with a significant decrease in both the severity of symptoms and the left atrial diameter." @default.
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- W4239759297 date "2006-06-01" @default.
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- W4239759297 title "EP News" @default.
- W4239759297 doi "https://doi.org/10.1016/j.hrthm.2006.04.005" @default.
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