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- W4239762556 abstract "Ixabepilone is an epothilone B analog. It is used for the treatment of aggressive metabolic or locally advanced breast cancer no longer responding to currently available chemotherapies. After an intravenous administration of 70 mg of [ 14 C]‐ixabepilone to eight patients, approximately 25 and 52% of the administered radioactivity were recovered in urine and feces, respectively, over the 168‐h collection period. In human plasma and urine, the unchanged ixabepilone was the predominant radioactive component. Metabolites produced through rearrangement/cyclization, hydration of the epoxide and hydroxylation/oxidation were detected. In human feces, ixabepilone was detected in a small amount of (<2% of the administered dose), and six metabolites were observed." @default.
- W4239762556 created "2022-05-12" @default.
- W4239762556 creator A5041463594 @default.
- W4239762556 date "2013-10-13" @default.
- W4239762556 modified "2023-09-26" @default.
- W4239762556 title "Ixabepilone" @default.
- W4239762556 cites W2055903345 @default.
- W4239762556 doi "https://doi.org/10.1002/9781118541203.xen195" @default.
- W4239762556 hasPublicationYear "2013" @default.
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