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- W4239772755 abstract "Abstract Purpose: We investigated the effect of ovary preserving surgery in early International Federation of Obstetrics and Gynecology (FIGO) stage endometrial cancer patients. Methods: Medical records were retrospectively reviewed for 539 patients who were diagnosed with early stage endometrial cancer between Jan 2006 and Dec 2017. Patients were categorized into ovary preservation and ovary removal groups. Demographics, recurrence free survival (RFS), and five-year overall survival (OS) rate were compared, and the clinical factors affecting survival were evaluated by univariate and multivariate analysis. Results: The median follow-up period was 85 months (range, 6-142 months), and the median age was 52.7 years. The mean age was higher in the ovary removal group than in the ovary preservation group (54.4 vs 40.94 years; P < 0.001). The ovary preservation group showed an earlier FIGO stage than the ovary removal group. ( P = 0.0264). There was a greater incidence of adjuvant chemotherapy administration in the removal group. There were no statistical differences in other baseline characteristics.When comparing the RFS and OS rates, there were no statistical differences between the preservation and removal groups. (recurrence free rate 98.5% vs 92.7%, p = 0.4360 , and 5-year survival rate 98.6% vs 93.0%, p = 0.0892 , respectively). Endometrioid histology ( p=0.006 ) and post-operative adjuvant chemotherapy ( p=0.0062 ) were related to OS, and adjuvant chemotherapy ( p<0.001 ) and radiotherapy ( p=0.005 ) were related to RFS Conclusions: Ovary preservation in early stage endometrial cancer is worth considering, as it does not affect survival in early stage endometrial cancer patients" @default.
- W4239772755 created "2022-05-12" @default.
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- W4239772755 date "2020-05-07" @default.
- W4239772755 modified "2023-09-22" @default.
- W4239772755 title "The Survival Effect of Ovary Preservation in Early Stage Endometrial Cancer: A Single Institution Retrospective Analysis" @default.
- W4239772755 doi "https://doi.org/10.21203/rs.3.rs-26398/v1" @default.
- W4239772755 hasPublicationYear "2020" @default.
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