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- W4239847075 abstract "Abstract Background: To evaluate the efficacy of oral clonazepam versus oral lorazepam following initial parenteral benzodiazepine administration to control methamphetamine-induced agitation in children. Methods: In a single-center clinical trial, intravenous diazepam (0.2 mg/Kg) was initially administered to all methamphetamine-poisoned pediatric patients to control their agitation, followed by a single dose of oral clonazepam (0.05 mg/Kg; n=15) or oral lorazepam (0.05 mg/Kg; n=15) to prevent relapse of toxicity. Results: The median age [IQR] (range) was 15 [ 10, 36] (6-144) months. The source of poisoning was methamphetamine exposure from oral ingestion in 23 (76.7%) and passive inhalation in 7 (23.3%) patients. The most common symptoms/signs were agitation (29; 96.7%), mydriatic pupils (26; 86.7%), and tachycardia (20; 66.6%). Two in each group (13.3%) needed re-administration of intravenous diazepam due to persistent agitation. There was no report of benzodiazepine complications in either group. Conclusions: Although both benzodiazepines were effective, considering the similar administered doses of oral clonazepam and lorazepam as well as the higher potency of clonazepam, it seems that lorazepam is a better suited oral benzodiazepine for the maintenance treatment of methamphetamine-induced agitation in children and can be used with minimal complications. Trial registration: IRCT20180610040036N2, April 18 th , 2020. Retrospectively registered" @default.
- W4239847075 created "2022-05-12" @default.
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- W4239847075 date "2020-08-10" @default.
- W4239847075 modified "2023-09-28" @default.
- W4239847075 title "Oral Clonazepam versus Lorazepam in the Treatment of Methamphetamine-Poisoned Children: A Pilot Clinical Trial" @default.
- W4239847075 doi "https://doi.org/10.21203/rs.3.rs-21359/v2" @default.
- W4239847075 hasPublicationYear "2020" @default.
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