FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239883757> ?p ?o ?g. }

• W4239883757 endingPage "3267" @default.
• W4239883757 startingPage "3260" @default.
• W4239883757 abstract "Platelet membrane glycoprotein IIIa (GPIIIa) is the most polymorphic integrin subunit in man, with at least seven recognized allelic isoforms present in the human gene pool. Whether these allelic variants of the GPIIb-IIIa complex differ in the ability to interact with the adhesive ligand fibrinogen (Fg) is still unknown. Since the Pena and Penb allelic forms of GPIIIa are distinguished by a single Arg143Gln amino acid substitution within the RGD binding domain of GPIIIa and anti-Pena human alloantibodies have been shown to bind GPIIb-IIIa on the platelet surface and inhibit ADP-induced platelet aggregation, we expressed both forms of this integrin in Chinese hamster ovary (CHO) cells and examined the relative adhesive properties. Both allelic forms of GPIIb-IIIa were expressed on the cell surface and were recognized by a well-characterized panel of murine and human monoclonal and polyclonal antibodies. Like Pena, the Penb form of GPIIb-IIIa could undergo conformational changes in response to RGD peptide binding, and could be induced by activating antibodies to bind Fg and the Fg mimetic antibody P1-55. The binding affinity for Fg of the Pena form of the GPIIb-IIIa complex was not significantly different from that of the Penb form, nor was its ability to signal to focal adhesion kinase, suggesting that Arg143Gln polymorphism has little or no effect on integrin function. Examination of the functional consequences of other integrin polymorphisms may be necessary to determine whether they constitute a risk factor for thrombosis or hemorrhage. © 1998 by The American Society of Hematology." @default.
• W4239883757 created "2022-05-12" @default.
• W4239883757 creator A5043749891 @default.
• W4239883757 creator A5050071143 @default.
• W4239883757 date "1998-11-01" @default.
• W4239883757 modified "2023-09-29" @default.
• W4239883757 title "Adhesive and Signaling Properties of a Naturally Occurring Allele of Glycoprotein IIIa With an Amino Acid Substitution Within the Ligand Binding Domain—The Pena/PenbPlatelet Alloantigenic Epitopes" @default.
• W4239883757 cites W1482108000 @default.
• W4239883757 cites W1486175763 @default.
• W4239883757 cites W1489612807 @default.
• W4239883757 cites W1542910811 @default.
• W4239883757 cites W1546132586 @default.
• W4239883757 cites W1562376535 @default.
• W4239883757 cites W1572190405 @default.
• W4239883757 cites W1590595696 @default.
• W4239883757 cites W1602182436 @default.
• W4239883757 cites W1605961154 @default.
• W4239883757 cites W1656991593 @default.
• W4239883757 cites W1965372133 @default.
• W4239883757 cites W1982509240 @default.
• W4239883757 cites W1987793565 @default.
• W4239883757 cites W2013984455 @default.
• W4239883757 cites W2014866625 @default.
• W4239883757 cites W2015623521 @default.
• W4239883757 cites W2029231027 @default.
• W4239883757 cites W2034599860 @default.
• W4239883757 cites W2081401313 @default.
• W4239883757 cites W2089562291 @default.
• W4239883757 cites W2093916196 @default.
• W4239883757 cites W2114814128 @default.
• W4239883757 cites W2121040201 @default.
• W4239883757 cites W2160639371 @default.
• W4239883757 cites W2341799510 @default.
• W4239883757 cites W2401185551 @default.
• W4239883757 cites W2410007954 @default.
• W4239883757 cites W2414934563 @default.
• W4239883757 cites W264187420 @default.
• W4239883757 cites W3110913815 @default.
• W4239883757 cites W4250142305 @default.
• W4239883757 doi "https://doi.org/10.1182/blood.v92.9.3260.421a08_3260_3267" @default.
• W4239883757 hasPublicationYear "1998" @default.
• W4239883757 type Work @default.
• W4239883757 citedByCount "0" @default.
• W4239883757 crossrefType "journal-article" @default.
• W4239883757 hasAuthorship W4239883757A5043749891 @default.
• W4239883757 hasAuthorship W4239883757A5050071143 @default.
• W4239883757 hasConcept C108625454 @default.
• W4239883757 hasConcept C153911025 @default.
• W4239883757 hasConcept C159654299 @default.
• W4239883757 hasConcept C170493617 @default.
• W4239883757 hasConcept C175656101 @default.
• W4239883757 hasConcept C195616568 @default.
• W4239883757 hasConcept C195687474 @default.
• W4239883757 hasConcept C203014093 @default.
• W4239883757 hasConcept C55493867 @default.
• W4239883757 hasConcept C86803240 @default.
• W4239883757 hasConcept C89560881 @default.
• W4239883757 hasConceptScore W4239883757C108625454 @default.
• W4239883757 hasConceptScore W4239883757C153911025 @default.
• W4239883757 hasConceptScore W4239883757C159654299 @default.
• W4239883757 hasConceptScore W4239883757C170493617 @default.
• W4239883757 hasConceptScore W4239883757C175656101 @default.
• W4239883757 hasConceptScore W4239883757C195616568 @default.
• W4239883757 hasConceptScore W4239883757C195687474 @default.
• W4239883757 hasConceptScore W4239883757C203014093 @default.
• W4239883757 hasConceptScore W4239883757C55493867 @default.
• W4239883757 hasConceptScore W4239883757C86803240 @default.
• W4239883757 hasConceptScore W4239883757C89560881 @default.
• W4239883757 hasIssue "9" @default.
• W4239883757 hasLocation W42398837571 @default.
• W4239883757 hasOpenAccess W4239883757 @default.
• W4239883757 hasPrimaryLocation W42398837571 @default.
• W4239883757 hasRelatedWork W1996802981 @default.
• W4239883757 hasRelatedWork W2056973121 @default.
• W4239883757 hasRelatedWork W2059347528 @default.
• W4239883757 hasRelatedWork W2064522855 @default.
• W4239883757 hasRelatedWork W2069869101 @default.
• W4239883757 hasRelatedWork W2078101902 @default.
• W4239883757 hasRelatedWork W2087420032 @default.
• W4239883757 hasRelatedWork W2336450040 @default.
• W4239883757 hasRelatedWork W2498190737 @default.
• W4239883757 hasRelatedWork W2899124813 @default.
• W4239883757 hasVolume "92" @default.
• W4239883757 isParatext "false" @default.
• W4239883757 isRetracted "false" @default.
• W4239883757 workType "article" @default.