FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239905103> ?p ?o ?g. }

• W4239905103 endingPage "6263" @default.
• W4239905103 startingPage "6253" @default.
• W4239905103 abstract "Serum amyloid A (SAA), one of the major acute-phase proteins, increases several hundredfold in concentration in plasma following acute inflammation, primarily as a result of a 200-fold increase in its transcriptional rate. Functional analysis of the rat SAA1 promoter has identified a 65-bp cytokine response unit (CRU; positions -135 to -71) that could confer cytokine responsiveness on a heterologous promoter. Within this CRU, two cis-regulatory elements, corresponding to NF-kappa B- and C/EBP-binding sites, were found to be functionally important and exerted synergistic effects on induced SAA1 expression. In this report, we show that a third transcription factor interacts with the CRU through a region located between the NF-kappa B- and C/EBP-binding sites. On the basis of its gel mobility shift patterns, ubiquitous binding activity, sequence specificity of DNA binding, zinc-dependent binding activity, and gel mobility supershift by specific antibodies, we concluded that this factor is identical to YY1. Methylation interference studies revealed that YY1 binding sequences overlapped with those of NF-kappa B, and gel mobility studies showed that NF-kappa binding to the CRU was effectively inhibited by YY1. Consistent with its presumed antagonistic role to NF-kappa B, YY1 exerted a negative effect on SAA1 expression, whereas disruption of its binding in the promoter elevated basal and cytokine-induced activities. Furthermore, overexpression of YY1 trans-repressed SAA1 promoter activity. Thus, our results demonstrate that SAA1 expression is tightly regulated by an on-off switch of activators and repressors, presumably to ensure that it is expressed only under appropriate physiological conditions." @default.
• W4239905103 created "2022-05-12" @default.
• W4239905103 creator A5021262821 @default.
• W4239905103 creator A5037256059 @default.
• W4239905103 creator A5077474550 @default.
• W4239905103 date "1994-09-01" @default.
• W4239905103 modified "2023-10-14" @default.
• W4239905103 title "YY1 represses rat serum amyloid A1 gene transcription and is antagonized by NF-kappa B during acute-phase response" @default.
• W4239905103 cites W102825632 @default.
• W4239905103 cites W1519171068 @default.
• W4239905103 cites W1520052348 @default.
• W4239905103 cites W1558516755 @default.
• W4239905103 cites W1592182146 @default.
• W4239905103 cites W1598873313 @default.
• W4239905103 cites W1658652867 @default.
• W4239905103 cites W1767630350 @default.
• W4239905103 cites W1798183867 @default.
• W4239905103 cites W1799635531 @default.
• W4239905103 cites W1867052108 @default.
• W4239905103 cites W1966156883 @default.
• W4239905103 cites W1968102722 @default.
• W4239905103 cites W1968424865 @default.
• W4239905103 cites W1972042181 @default.
• W4239905103 cites W1973031832 @default.
• W4239905103 cites W1975987535 @default.
• W4239905103 cites W1982108913 @default.
• W4239905103 cites W1984021794 @default.
• W4239905103 cites W1995184275 @default.
• W4239905103 cites W1996584284 @default.
• W4239905103 cites W2014569682 @default.
• W4239905103 cites W2018352453 @default.
• W4239905103 cites W2026548183 @default.
• W4239905103 cites W2027569621 @default.
• W4239905103 cites W2030046231 @default.
• W4239905103 cites W2033777731 @default.
• W4239905103 cites W2037602867 @default.
• W4239905103 cites W2042688292 @default.
• W4239905103 cites W2048066878 @default.
• W4239905103 cites W2061903251 @default.
• W4239905103 cites W2068577315 @default.
• W4239905103 cites W2075165827 @default.
• W4239905103 cites W2075840772 @default.
• W4239905103 cites W2081710784 @default.
• W4239905103 cites W2083490046 @default.
• W4239905103 cites W2085236534 @default.
• W4239905103 cites W2085712403 @default.
• W4239905103 cites W2086527757 @default.
• W4239905103 cites W2095953267 @default.
• W4239905103 cites W2118516988 @default.
• W4239905103 cites W2132781864 @default.
• W4239905103 cites W2144206181 @default.
• W4239905103 cites W2159511823 @default.
• W4239905103 cites W2301712053 @default.
• W4239905103 cites W4232422455 @default.
• W4239905103 cites W4237015617 @default.
• W4239905103 cites W4293247451 @default.
• W4239905103 doi "https://doi.org/10.1128/mcb.14.9.6253-6263.1994" @default.
• W4239905103 hasPublicationYear "1994" @default.
• W4239905103 type Work @default.
• W4239905103 citedByCount "3" @default.
• W4239905103 crossrefType "journal-article" @default.
• W4239905103 hasAuthorship W4239905103A5021262821 @default.
• W4239905103 hasAuthorship W4239905103A5037256059 @default.
• W4239905103 hasAuthorship W4239905103A5077474550 @default.
• W4239905103 hasConcept C101762097 @default.
• W4239905103 hasConcept C104317684 @default.
• W4239905103 hasConcept C107824862 @default.
• W4239905103 hasConcept C150194340 @default.
• W4239905103 hasConcept C153911025 @default.
• W4239905103 hasConcept C158448853 @default.
• W4239905103 hasConcept C183978625 @default.
• W4239905103 hasConcept C203014093 @default.
• W4239905103 hasConcept C2776914184 @default.
• W4239905103 hasConcept C55359608 @default.
• W4239905103 hasConcept C55493867 @default.
• W4239905103 hasConcept C57194454 @default.
• W4239905103 hasConcept C62944979 @default.
• W4239905103 hasConcept C86339819 @default.
• W4239905103 hasConcept C86803240 @default.
• W4239905103 hasConcept C94966510 @default.
• W4239905103 hasConceptScore W4239905103C101762097 @default.
• W4239905103 hasConceptScore W4239905103C104317684 @default.
• W4239905103 hasConceptScore W4239905103C107824862 @default.
• W4239905103 hasConceptScore W4239905103C150194340 @default.
• W4239905103 hasConceptScore W4239905103C153911025 @default.
• W4239905103 hasConceptScore W4239905103C158448853 @default.
• W4239905103 hasConceptScore W4239905103C183978625 @default.
• W4239905103 hasConceptScore W4239905103C203014093 @default.
• W4239905103 hasConceptScore W4239905103C2776914184 @default.
• W4239905103 hasConceptScore W4239905103C55359608 @default.
• W4239905103 hasConceptScore W4239905103C55493867 @default.
• W4239905103 hasConceptScore W4239905103C57194454 @default.
• W4239905103 hasConceptScore W4239905103C62944979 @default.
• W4239905103 hasConceptScore W4239905103C86339819 @default.
• W4239905103 hasConceptScore W4239905103C86803240 @default.
• W4239905103 hasConceptScore W4239905103C94966510 @default.
• W4239905103 hasIssue "9" @default.
• W4239905103 hasLocation W42399051031 @default.

• next