FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239920997> ?p ?o ?g. }

• W4239920997 endingPage "S28" @default.
• W4239920997 startingPage "S28" @default.
• W4239920997 abstract "Purpose Digoxin use has been associated with reduced rate of gastrointestinal bleeding (GIB) in a previous study of patients on left ventricular assistive device (LVAD) support. The purpose of this study was to test the association between digoxin use and GIB events in a large, multicenter, contemporary dataset inclusive of HeartMate 3 devices. Methods Patients with complete data on GIB events and digoxin use from two medical centers were included in the analysis (total n=650). GI bleeding events were captured out to 2 years of follow up and digoxin use was defined as digoxin prescribed at discharge or within the first 3 months after LVAD implantation. A negative binomial regression model was performed to determine association between digoxin use and number of GI bleeding events over 2 years of LVAD support. Results Mean age of the study cohort was 57 years (±14), 45 % were bridge to transplant (BTT), and 78% had HeartMate 2 devices. Thirteen % received HeartMate 3 devices. Digoxin was prescribed in 31% of patients. Patients on digoxin had better renal function at the time of LVAD implantation (1.19 vs 1.21, P= 0.037), lower INTERMACS profile (INTERMACS 2-3: 56 % vs. 48 %, P<0.001) and were less likely to be designated BTT (33% vs 51%, P < 0.001). Digoxin use was associated with a reduction in the incidence rate of GI bleeding on LVAD support (unadjusted 35% reduction in incidence rate ratio (IRR), 95% CI 3-56 % reduction, p =0.034, adjusted 36% reduction in IRR, 95% CI 3-58 % reduction, p =0.038). The final model was adjusted for age, INTERMACS profile, BTT status, creatinine, right atrial pressure and ace-inhibitor or angiotensin receptor blocker use. Conclusion In this large multicenter study, inclusive of the most contemporary devices, digoxin use was associated with reduced GI bleeding events. Prospective data will be required to confirm this hypothesis. Digoxin use has been associated with reduced rate of gastrointestinal bleeding (GIB) in a previous study of patients on left ventricular assistive device (LVAD) support. The purpose of this study was to test the association between digoxin use and GIB events in a large, multicenter, contemporary dataset inclusive of HeartMate 3 devices. Patients with complete data on GIB events and digoxin use from two medical centers were included in the analysis (total n=650). GI bleeding events were captured out to 2 years of follow up and digoxin use was defined as digoxin prescribed at discharge or within the first 3 months after LVAD implantation. A negative binomial regression model was performed to determine association between digoxin use and number of GI bleeding events over 2 years of LVAD support. Mean age of the study cohort was 57 years (±14), 45 % were bridge to transplant (BTT), and 78% had HeartMate 2 devices. Thirteen % received HeartMate 3 devices. Digoxin was prescribed in 31% of patients. Patients on digoxin had better renal function at the time of LVAD implantation (1.19 vs 1.21, P= 0.037), lower INTERMACS profile (INTERMACS 2-3: 56 % vs. 48 %, P<0.001) and were less likely to be designated BTT (33% vs 51%, P < 0.001). Digoxin use was associated with a reduction in the incidence rate of GI bleeding on LVAD support (unadjusted 35% reduction in incidence rate ratio (IRR), 95% CI 3-56 % reduction, p =0.034, adjusted 36% reduction in IRR, 95% CI 3-58 % reduction, p =0.038). The final model was adjusted for age, INTERMACS profile, BTT status, creatinine, right atrial pressure and ace-inhibitor or angiotensin receptor blocker use. In this large multicenter study, inclusive of the most contemporary devices, digoxin use was associated with reduced GI bleeding events. Prospective data will be required to confirm this hypothesis." @default.
• W4239920997 created "2022-05-12" @default.
• W4239920997 creator A5000805461 @default.
• W4239920997 creator A5007458632 @default.
• W4239920997 creator A5046078505 @default.
• W4239920997 creator A5046678187 @default.
• W4239920997 creator A5047803355 @default.
• W4239920997 creator A5053472875 @default.
• W4239920997 creator A5054612339 @default.
• W4239920997 creator A5056191716 @default.
• W4239920997 creator A5079805383 @default.
• W4239920997 date "2020-04-01" @default.
• W4239920997 modified "2023-09-23" @default.
• W4239920997 title "Association between Digoxin Use and Gastrointestinal Bleeding in Contemporary Continuous Flow Left Ventricular Assist Device Support" @default.
• W4239920997 doi "https://doi.org/10.1016/j.healun.2020.01.1170" @default.
• W4239920997 hasPublicationYear "2020" @default.
• W4239920997 type Work @default.
• W4239920997 citedByCount "0" @default.
• W4239920997 crossrefType "journal-article" @default.
• W4239920997 hasAuthorship W4239920997A5000805461 @default.
• W4239920997 hasAuthorship W4239920997A5007458632 @default.
• W4239920997 hasAuthorship W4239920997A5046078505 @default.
• W4239920997 hasAuthorship W4239920997A5046678187 @default.
• W4239920997 hasAuthorship W4239920997A5047803355 @default.
• W4239920997 hasAuthorship W4239920997A5053472875 @default.
• W4239920997 hasAuthorship W4239920997A5054612339 @default.
• W4239920997 hasAuthorship W4239920997A5056191716 @default.
• W4239920997 hasAuthorship W4239920997A5079805383 @default.
• W4239920997 hasConcept C111472728 @default.
• W4239920997 hasConcept C121332964 @default.
• W4239920997 hasConcept C126322002 @default.
• W4239920997 hasConcept C138885662 @default.
• W4239920997 hasConcept C142853389 @default.
• W4239920997 hasConcept C164705383 @default.
• W4239920997 hasConcept C2777707475 @default.
• W4239920997 hasConcept C2778080469 @default.
• W4239920997 hasConcept C2778198053 @default.
• W4239920997 hasConcept C2778774980 @default.
• W4239920997 hasConcept C2985264121 @default.
• W4239920997 hasConcept C57879066 @default.
• W4239920997 hasConcept C71924100 @default.
• W4239920997 hasConceptScore W4239920997C111472728 @default.
• W4239920997 hasConceptScore W4239920997C121332964 @default.
• W4239920997 hasConceptScore W4239920997C126322002 @default.
• W4239920997 hasConceptScore W4239920997C138885662 @default.
• W4239920997 hasConceptScore W4239920997C142853389 @default.
• W4239920997 hasConceptScore W4239920997C164705383 @default.
• W4239920997 hasConceptScore W4239920997C2777707475 @default.
• W4239920997 hasConceptScore W4239920997C2778080469 @default.
• W4239920997 hasConceptScore W4239920997C2778198053 @default.
• W4239920997 hasConceptScore W4239920997C2778774980 @default.
• W4239920997 hasConceptScore W4239920997C2985264121 @default.
• W4239920997 hasConceptScore W4239920997C57879066 @default.
• W4239920997 hasConceptScore W4239920997C71924100 @default.
• W4239920997 hasIssue "4" @default.
• W4239920997 hasLocation W42399209971 @default.
• W4239920997 hasOpenAccess W4239920997 @default.
• W4239920997 hasPrimaryLocation W42399209971 @default.
• W4239920997 hasRelatedWork W11094590 @default.
• W4239920997 hasRelatedWork W11997918 @default.
• W4239920997 hasRelatedWork W12585237 @default.
• W4239920997 hasRelatedWork W14905088 @default.
• W4239920997 hasRelatedWork W15268238 @default.
• W4239920997 hasRelatedWork W17020087 @default.
• W4239920997 hasRelatedWork W18498142 @default.
• W4239920997 hasRelatedWork W19723568 @default.
• W4239920997 hasRelatedWork W563754 @default.
• W4239920997 hasRelatedWork W9070863 @default.
• W4239920997 hasVolume "39" @default.
• W4239920997 isParatext "false" @default.
• W4239920997 isRetracted "false" @default.
• W4239920997 workType "article" @default.