Matches in SemOpenAlex for { <https://semopenalex.org/work/W4239954108> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4239954108 endingPage "4408" @default.
- W4239954108 startingPage "4396" @default.
- W4239954108 abstract "Proteins encoded by oncogenes such as v-fps/fes, v-src, v-yes, v-abl, and v-fgr are cytoplasmic protein tyrosine kinases which, unlike transmembrane receptors, are localized to the inside of the cell. These proteins possess two contiguous regions of sequence identity: a C-terminal catalytic domain of 260 residues with homology to other tyrosine-specific and serine-threonine-specific protein kinases, and a unique domain of approximately 100 residues which is located N terminal to the kinase region and is absent from kinases that span the plasma membrane. In-frame linker insertion mutations in Fujinami avian sarcoma virus which introduced dipeptide insertions into the most stringently conserved segment of this N-terminal domain in P130gag-fps impaired the ability of Fujinami avian sarcoma virus to transform rat-2 cells. The P130gag-fps proteins encoded by these transformation-defective mutants were deficient in protein-tyrosine kinase activity in rat cells. However v-fps polypeptides derived from the mutant Fujinami avian sarcoma virus genomes and expressed in Escherichia coli as trpE-v-fps fusion proteins displayed essentially wild-type enzymatic activity, even though they contained the mutated sites. Deletion of the N-terminal domain from wild-type and mutant v-fps bacterial proteins had little effect on autophosphorylating activity. The conserved N-terminal domain of P130gag-fps is therefore not required for catalytic activity, but can profoundly influence the adjacent kinase region. The presence of this noncatalytic domain in all known cytoplasmic tyrosine kinases of higher and lower eucaryotes argues for an important biological function. The relative inactivity of the mutant proteins in rat-2 cells compared with bacteria suggests that the noncatalytic domain may direct specific interactions of the enzymatic region with cellular components that regulate or mediate tyrosine kinase function." @default.
- W4239954108 created "2022-05-12" @default.
- W4239954108 creator A5052555731 @default.
- W4239954108 creator A5072549811 @default.
- W4239954108 creator A5076609696 @default.
- W4239954108 date "1986-12-01" @default.
- W4239954108 modified "2023-10-14" @default.
- W4239954108 title "A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps." @default.
- W4239954108 doi "https://doi.org/10.1128/mcb.6.12.4396" @default.
- W4239954108 hasPublicationYear "1986" @default.
- W4239954108 type Work @default.
- W4239954108 citedByCount "251" @default.
- W4239954108 countsByYear W42399541082012 @default.
- W4239954108 countsByYear W42399541082013 @default.
- W4239954108 countsByYear W42399541082014 @default.
- W4239954108 countsByYear W42399541082015 @default.
- W4239954108 countsByYear W42399541082016 @default.
- W4239954108 countsByYear W42399541082017 @default.
- W4239954108 countsByYear W42399541082018 @default.
- W4239954108 countsByYear W42399541082019 @default.
- W4239954108 countsByYear W42399541082020 @default.
- W4239954108 countsByYear W42399541082021 @default.
- W4239954108 countsByYear W42399541082022 @default.
- W4239954108 countsByYear W42399541082023 @default.
- W4239954108 crossrefType "journal-article" @default.
- W4239954108 hasAuthorship W4239954108A5052555731 @default.
- W4239954108 hasAuthorship W4239954108A5072549811 @default.
- W4239954108 hasAuthorship W4239954108A5076609696 @default.
- W4239954108 hasBestOaLocation W42399541082 @default.
- W4239954108 hasConcept C101544691 @default.
- W4239954108 hasConcept C104317684 @default.
- W4239954108 hasConcept C108636557 @default.
- W4239954108 hasConcept C123894998 @default.
- W4239954108 hasConcept C143065580 @default.
- W4239954108 hasConcept C153911025 @default.
- W4239954108 hasConcept C184235292 @default.
- W4239954108 hasConcept C196347352 @default.
- W4239954108 hasConcept C197153747 @default.
- W4239954108 hasConcept C2776165026 @default.
- W4239954108 hasConcept C2777441520 @default.
- W4239954108 hasConcept C32619005 @default.
- W4239954108 hasConcept C40767141 @default.
- W4239954108 hasConcept C42362537 @default.
- W4239954108 hasConcept C55493867 @default.
- W4239954108 hasConcept C62478195 @default.
- W4239954108 hasConcept C86803240 @default.
- W4239954108 hasConcept C95444343 @default.
- W4239954108 hasConceptScore W4239954108C101544691 @default.
- W4239954108 hasConceptScore W4239954108C104317684 @default.
- W4239954108 hasConceptScore W4239954108C108636557 @default.
- W4239954108 hasConceptScore W4239954108C123894998 @default.
- W4239954108 hasConceptScore W4239954108C143065580 @default.
- W4239954108 hasConceptScore W4239954108C153911025 @default.
- W4239954108 hasConceptScore W4239954108C184235292 @default.
- W4239954108 hasConceptScore W4239954108C196347352 @default.
- W4239954108 hasConceptScore W4239954108C197153747 @default.
- W4239954108 hasConceptScore W4239954108C2776165026 @default.
- W4239954108 hasConceptScore W4239954108C2777441520 @default.
- W4239954108 hasConceptScore W4239954108C32619005 @default.
- W4239954108 hasConceptScore W4239954108C40767141 @default.
- W4239954108 hasConceptScore W4239954108C42362537 @default.
- W4239954108 hasConceptScore W4239954108C55493867 @default.
- W4239954108 hasConceptScore W4239954108C62478195 @default.
- W4239954108 hasConceptScore W4239954108C86803240 @default.
- W4239954108 hasConceptScore W4239954108C95444343 @default.
- W4239954108 hasIssue "12" @default.
- W4239954108 hasLocation W42399541081 @default.
- W4239954108 hasLocation W42399541082 @default.
- W4239954108 hasLocation W42399541083 @default.
- W4239954108 hasLocation W42399541084 @default.
- W4239954108 hasOpenAccess W4239954108 @default.
- W4239954108 hasPrimaryLocation W42399541081 @default.
- W4239954108 hasRelatedWork W1812955231 @default.
- W4239954108 hasRelatedWork W1829425822 @default.
- W4239954108 hasRelatedWork W2000164723 @default.
- W4239954108 hasRelatedWork W2043306215 @default.
- W4239954108 hasRelatedWork W2159452410 @default.
- W4239954108 hasRelatedWork W2631549882 @default.
- W4239954108 hasRelatedWork W2788946215 @default.
- W4239954108 hasRelatedWork W3029756893 @default.
- W4239954108 hasRelatedWork W4241010438 @default.
- W4239954108 hasRelatedWork W4317745817 @default.
- W4239954108 hasVolume "6" @default.
- W4239954108 isParatext "false" @default.
- W4239954108 isRetracted "false" @default.
- W4239954108 workType "article" @default.