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- W4239973662 abstract "This chapter presents the diagnosis and treatment for retinal toxicity in cats and dogs. Sensitive neuroretinal tissues may be damaged by exposure to potentially harmful pharmacologic agents, frequently enrofloxacin in cats and ivermectin in dogs. Toxicity associated with enrofloxacin in cats may result in varying degrees of visual impairment/blindness. Toxicity associated with ivermectin may result in varying degrees of visual impairment/blindness as well as neurological defects, altered mentation, and/or thermal dysregulation. Collie breeds including the Australian Shepherd and Shetland Sheepdog are potentially more susceptible to ivermectin toxicity because of a hereditary defect associated with the MDR1 gene, which regulates molecular transport at the level of the blood–brain barrier. Clinical findings and history help in the diagnosis of retinal toxicity. Electroretinography (ERG) is to evaluate photoreceptor function. Treatment comprises drug withdrawal and supportive care. Changes associated with enrofloxacin toxicity are generally irreversible. Those associated with ivermectin toxicity are frequently reversible." @default.
- W4239973662 created "2022-05-12" @default.
- W4239973662 date "2015-05-20" @default.
- W4239973662 modified "2023-09-23" @default.
- W4239973662 title "Retinal Toxicity" @default.
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- W4239973662 doi "https://doi.org/10.1002/9781118840801.ch115" @default.
- W4239973662 hasPublicationYear "2015" @default.
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